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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Development of an Anti-Atherosclerotic Polyherbal Formulation: GSTC3

Volume 34, Edição 3, 2015, pp. 237-248
DOI: 10.1615/JEnvironPatholToxicolOncol.2015012673
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RESUMO

A polyherbal formulation consisting of different proportions of Commiphora mukul (Hook ex Stocks) Eng., Salacia reticulata Wight, Terminalia arjuna (Roxb.) Wight & Arn, and Curcuma longa Linn extracts was tested for free-radical scavenging and anti-lipid peroxidative effects on serum and platelets in vitro. The most active formulation (GSTC3) was evaluated for its hypolipidemic potential on a high-fat, high-cholesterol diet (HFD) fed to male Wistar rats for a period of 45 days. At a dose of 100 mg/kg body weight, GSTC3 decreased serum total cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), triglycerides, and phospholipids similar to standard atorvastatin while maintaining high-density lipoprotein (HDL) at normal levels. Significantly lower levels of thiobarbituric acid−reactive substances (TBARS) were observed in both the liver and sera of rats treated with GSTC3. Although the phospholipid levels in liver remained unchanged, lower values of LDL, VLDL, and atherogenic index of plasma as well as higher HMG-CoA/ mevalonate ratios suggested a significant hypolipidemic effect for GSTC3, possibly by partial inhibition of HMG-CoA reductase activity. The histopathological analysis of liver tissue did not reveal lipid accumulation or indicate tissue damage. Overall, the results of this study suggest the hypolipidemic and anti-atherogenic efficacy of a nontoxic herbal formulation.

CITADO POR
  1. Lekshmi Sheela Devi, Nazeem Puthiyaveetil Abdulla, Narayanankutty Arunaksharan, Manalil Jeksy Jos, Raghavamenon Achuthan C., In Silico and Wet Lab Studies Reveal the Cholesterol Lowering Efficacy of Lauric Acid, a Medium Chain Fat of Coconut Oil, Plant Foods for Human Nutrition, 71, 4, 2016. Crossref

  2. Perry Luba, Ben-Shaul Shahar, Landau Shira, Levenberg Shulamit, Co-Culture Systems for Vasculogenesis, in Vascularization for Tissue Engineering and Regenerative Medicine, 2017. Crossref

  3. Narayanankutty Arunaksharan, Anil Anu, Illam Soorya Parathodi, Kandiyil Sruthi Panniyan, Raghavamenon Achuthan C., Non-polar lipid carbonyls of thermally oxidized coconut oil induce hepatotoxicity mediated by redox imbalance, Prostaglandins, Leukotrienes and Essential Fatty Acids, 138, 2018. Crossref

  4. Chaliha Mridusmita, Sultanbawa Yasmina, Terminalia ferdinandiana, a traditional medicinal plant of Australia, alleviates hydrogen peroxide induced oxidative stress and inflammation, in vitro, Journal of Complementary and Integrative Medicine, 17, 1, 2019. Crossref

  5. Chinchu J.U., Mohan Mohind C., Prakash Kumar B., Anti-obesity and lipid lowering effects of Varanadi kashayam (decoction) on high fat diet induced obese rats, Obesity Medicine, 17, 2020. Crossref

  6. Perry Luba, Ben-Shaul Shahar, Landau Shira, Levenberg Shulamit, Co-culture Systems for Vasculogenesis, in Vascularization for Tissue Engineering and Regenerative Medicine, 2021. Crossref

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