Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Chemopreventive Efficacy of (+)-Catechin-Rich Aqueous Extract of Acacia catechu Willd. Heartwood against 7,12-Dimethylbenz[a]Anthracene-Induced Hepatocarcinoma in Balb/c Mice
RESUMO
The objective of this study was to investigate the chemopreventive potential of (+)-catechin-rich extract of Acacia catechu heartwood (AQCE) against 7,12-dimethylbenz[a]anthracene (DMBA)-induced hepatocellular carcinoma in Balb/c mice. The levels of liver injury markers, tumor markers, and oxidative stress were measured in serum and liver tissues. Furthermore, the levels of transcription factors were measured by ELISA. Tumor incidence was found to be 100% in DMBA-treated animals (group 2), whereas, in AQCE-treated animals (group 3), it was 37.5%. AQCE treatment reduced liver injury and restored tumor-marker levels. AQCE also significantly reduced elevated levels of nitrite and hepatic malondialdehyde (MDA) in DMBA-treated animals. Additionally, AQCE modulated the activity of different antioxidant enzymes in liver tissues. Eventually, AQCE also significantly improved body weight, prevented the increase of relative liver weight, and maintained the liver cellular architecture within the normal range of the control. A significant increase in the protein levels of p53, c-jun, and NF-κB (p65) were observed in DMBA-treated mice, whereas low levels of these markers were observed in DMBA+AQCE-treated animals. These findings strongly suggest (1) that (+)-catechin-rich AQCE exerts a chemopreventive effect by modulating the levels of lipid peroxidation and by promoting the enzymatic and non-enzymatic antioxidant defense system and (2) that this effect is linked to the expression of transcription factors during hepatocarcinogenesis.
-
Al-Mohizea Abdullah Mohammed, Raish Mohammad, Ahad Abdul, Al-Jenoobi Fahad Ibrahim, Alam Mohd Aftab, Pharmacokinetic interaction of Acacia catechu with CYP1A substrate theophylline in rabbits, Journal of Traditional Chinese Medicine, 35, 5, 2015. Crossref
-
Stohs Sidney J., Bagchi Debasis, Antioxidant, Anti‐inflammatory, and Chemoprotective Properties of Acacia catechu Heartwood Extracts , Phytotherapy Research, 29, 6, 2015. Crossref
-
Monga Jitender, Aggarwal Vaibhav, Suthar Sharad Kumar, Monika Monika, Nongalleima Khumukcham, Sharma Manu, Topical (+)-catechin emulsified gel prevents DMBA/TPA-induced squamous cell carcinoma of the skin by modulating antioxidants and inflammatory biomarkers in BALB/c mice, Food Funct., 5, 12, 2014. Crossref
-
Kujawska Małgorzata, Ewertowska Małgorzata, Adamska Teresa, Ignatowicz Ewa, Gramza-Michałowska Anna, Jodynis-Liebert Jadwiga, Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis, Pharmaceutical Biology, 54, 9, 2016. Crossref
-
Akbar Shahid, Acacia catechu Oliver (Fabaceae/Leguminosae), in Handbook of 200 Medicinal Plants, 2020. Crossref