Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Radioprotection of Swiss albino mice by Prunus avium with special reference to hematopoietic system
RESUMO
Prunus avium (family Rosaceae) has been used ethnomedicinally for the treatment of many diseases, but its radioprotective efficacy has hardly been explored. Presence of high anthocyanin content and phenolic compound with good antioxidative capacity has been reported by researchers. Its radioprotective effect against 5, 7, 10 and 12 Gy gamma radiation was evaluated by 30 day survival assay. Regression analysis yielded LD50/30 5.81 and 9.43Gy for irradiated only and PAE + radiation groups, respectively. The Dose Reduction Factor (DRF) was computed as 1.62. For biochemical and hematological studies, Swiss albino mice were divided into four groups: (1) control (vehicle treated); (2) PAE (P. avium fruit extract) treated (450 mg kg/day for 15 consequetive days); (3) irradiated (5 Gy) and (4) PAE + irradiated. The irradiation of animals resulted in a significant elevation of lipid peroxidation and depletion in glutathione and protein levels in blood serum and spleen which could be significantly checked by administration of PAE. Radiation induced deficit in blood sugar, cholesterol and hematological constituents could also be modulated by supplementation of PAE before and after irradiation. The possible prophylactic and therapeutic action noted by P. avium against radiation-induced metabolic disorders may be due to synergistic action of various antioxidants, minerals, vitamins etc. present in the fruit. Further mechanistic studies aimed at identifying the role of major ingredients in the extract are needed.
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Sharma Archana, Sisodia Rashmi, Bhatnagar Deepak, Saxena Virendra Kumar, Spatial memory and learning performance and its relationship to protein synthesis of Swiss albino mice exposed to 10 GHz microwaves, International Journal of Radiation Biology, 90, 1, 2014. Crossref
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Lim T. K., Prunus avium, in Edible Medicinal And Non-Medicinal Plants, 2012. Crossref
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Haritwal Teena, Tiwari Mrinalini, Agrawala Paban, Herbal Radioprotectors: A mini-review of the Current Status, Natural Resources for Human Health, 2, 2, 2022. Crossref
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Shivappa Pooja, Bernhardt GrisildaVidya, Natural radioprotectors on current and future perspectives: A mini-review, Journal of Pharmacy And Bioallied Sciences, 14, 2, 2022. Crossref