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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Neurosteroids and Ischemic Stroke: Progesterone a Promising Agent in Reducing the Brain Injury in Ischemic Stroke

Volume 36, Edição 3, 2017, pp. 191-205
DOI: 10.1615/JEnvironPatholToxicolOncol.2017017156
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RESUMO

Progesterone (P4), a well-known neurosteroid, is produced by ovaries and placenta in females and by adrenal glands in both sexes. Progesterone is also synthesized by central nervous system (CNS) tissues to perform various vital neurological functions in the brain. Apart from performing crucial reproductive functions, it also plays a pivotal role in neurogenesis, regeneration, cognition, mood, inflammation, and myelination in the CNS. A substantial body of experimental evidence from animal models documents the neuroprotective role of P4 in various CNS injury models, including ischemic stroke. Extensive data have revealed that P4 elicits neuroprotection through multiple mechanisms and systems in an integrated manner to prevent neuronal and glial damage, thus reducing mortality and morbidity. Progesterone has been described as safe for use at the clinical level through different routes in several studies. Data regarding the neuroprotective role of P4 in ischemic stroke are of great interest due to their potential clinical implications. In this review, we succinctly discuss the biosynthesis of P4 and distribution of P4 receptors (PRs) in the brain. We summarize our work on the general mechanisms of P4 mediated via the modulation of different PR and neurotransmitters. Finally, we describe the neuroprotective mechanisms of P4 in ischemic stroke models and related clinical prospects.

CITADO POR
  1. Stanojlović Miloš, Guševac Stojanović Ivana, Zarić Marina, Martinović Jelena, Mitrović Nataša, Grković Ivana, Drakulić Dunja, Progesterone Protects Prefrontal Cortex in Rat Model of Permanent Bilateral Common Carotid Occlusion via Progesterone Receptors and Akt/Erk/eNOS, Cellular and Molecular Neurobiology, 40, 5, 2020. Crossref

  2. Andrabi Syed Suhail, Parvez Suhel, Tabassum Heena, Ischemic stroke and mitochondria: mechanisms and targets, Protoplasma, 257, 2, 2020. Crossref

  3. Hobeika Elie, Armouti Marah, Kala Hamsini Sudheer, Stocco Carlos, Ovarian Hormones, in Hormonal Signaling in Biology and Medicine, 2020. Crossref

  4. Del Río Juan Pablo, Molina Santiago, Hidalgo-Lanussa Oscar, Garcia-Segura Luis Miguel, Barreto George E., Tibolone as Hormonal Therapy and Neuroprotective Agent, Trends in Endocrinology & Metabolism, 31, 10, 2020. Crossref

  5. Leonard Brian E., Neurotransmission and Mechanisms of Drug Action, in Seminars in Clinical Psychopharmacology, 2020. Crossref

  6. Lan Cong, Cao Nian, Chen Caiyu, Qu Shuang, Fan Chao, Luo Hao, Zeng Andi, Yu Cheng, Xue Yuanzheng, Ren Hongmei, Li Liangpeng, Wang Hongyong, Jose Pedro A., Xu Zaicheng, Zeng Chunyu, Progesterone, via yes‐associated protein, promotes cardiomyocyte proliferation and cardiac repair, Cell Proliferation, 53, 11, 2020. Crossref

  7. Liu Xuenan, Lian Xiaomin, Liu Xuejiao, Du Yangge, Zhu Yuan, Hu Menglong, Zhang Ping, Liu Yunsong, Zhou Yongsheng, Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor, Stem Cell Research & Therapy, 12, 1, 2021. Crossref

  8. Khassafi Negar, Zahraei Zohreh, Vahidinia Zeinab, Karimian Mohammad, Azami Tameh Abolfazl, Calcitriol Pretreatment Attenuates Glutamate Neurotoxicity by Regulating NMDAR and CYP46A1 Gene Expression in Rats Subjected to Transient Middle Cerebral Artery Occlusion, Journal of Neuropathology & Experimental Neurology, 81, 4, 2022. Crossref

  9. Feng Linying, Gao Jianmei, Liu Yuangui, Shi Jingshan, Gong Qihai, Icariside II alleviates oxygen-glucose deprivation and reoxygenation-induced PC12 cell oxidative injury by activating Nrf2/SIRT3 signaling pathway, Biomedicine & Pharmacotherapy, 103, 2018. Crossref

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