Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Heavy Metal−Induced Systemic Dysfunction Attenuated by Tannic Acid
RESUMO
Lead toxicity is a major public health concern. This study was designed to investigate the effects of oral administration of tannic acid (TA) on lead acetate (LA)−induced oxidative stress in rat liver and kidney. Rats were treated with 50 mg/kg body weight of TA against LA-induced oxidative stress 3 times/week for 2 weeks. At a rate of 50 mg/kg of body weight, LA was given intraperitoneally 3 times/week for 2 weeks. Results show significantly elevated levels of oxidative stress markers observed in LA-treated rats, whereas significant depletion in the activity of nonenzymatic and enzymatic antioxidants as well as histological changes were observed in LA-treated rat liver and kidney. TA treatment significantly attenuated the altered levels of oxidative stress biomarkers for nonenzymatic and enzymatic antioxidants. We demonstrated that TA exhibits potent antioxidant and protected against oxidative damage in rat liver and kidney induced by LA treatment. These findings were further supported by histopathological findings in liver and kidney showing that TA protected tissue from the deleterious effects of LA treatment. These outcomes suggest that the consumption of TA may confer a protective effect against lead intoxication through its antioxidative effect.
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Dar Mohd. Shafi, Mittal Deepak Kumar, Tabasum Shazia, Antioxidant, Anti-inflammatory and hepatoprotective activities of Persicaria maculosa (linn.) and its active principle i.e tannic acid against Carbon tetrachloride induced oxidative stress and hepatotoxicity in wistar rats, IP International Journal of Forensic Medicine and Toxicological Sciences, 7, 1, 2022. Crossref
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Li Ning, Wen Liuding, Yu Zengli, Li Tiange, Wang Tianlin, Qiao Mingwu, Song Lianjun, Huang Xianqing, Effects of folic acid on oxidative damage of kidney in lead-exposed rats, Frontiers in Nutrition, 9, 2022. Crossref