Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Biochemical Manipulation via Iron Chelation to Enhance Porphyrin Production from Porphyrin Precursors
RESUMO
Topical protoporphyrin IX (PPIX) induced photodynamic therapy (PDT) of basal cell carcinoma (BCC) produces good clinical outcomes with excellent cosmesis as long as the disease remains superficial. Efficacy for nodular BCC, however, appears inferior to standard treatment unless repeat treatments are performed. Enhancement is therefore required and may be possible by employing iron chelating agents to temporarily increase PPIX accumulation above the levels normally obtained using aminolaevulinic acid (ALA) or the methyl ester of ALA (MAL) alone. In vitro studies investigated the efficacies of the novel iron chelator, CP94 (1,2-diethyl-3-hydroxypyridin-4-one hydrochloride), and the established iron chelator, desferrioxamine (DFO), at increasing PPIX fluorescence in cultured human lung fibroblasts and squamous carcinoma cells incubated with ALA/MAL. CP94 was found to produce greater PPIX fluorescence when administered with ALA/MAL than either congener could produce alone. CP94 was also found to be superior to DFO in the enhancement of PPIX fluorescence and could be employed to accumulate the same levels of PPIX within a shorter time period. Clinical utilization of CP94 to enhance ALA/MAL-PDT could potentially result in greater PPIX accumulation or alternatively could be employed to reduce the length of the required drug-light interval. Clinical investigation of this is currently underway.
-
Tayyaba Hasan, Rai Prakash R., Verma Sarika, Zheng Xiang, Molecular Targeting of Photosensitizers, in Handbook of Biophotonics, 2013. Crossref
-
Blake E., Allen J., Thorn C., Shore A., Curnow A., Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy, Lasers in Medical Science, 28, 3, 2013. Crossref
-
Juzeniene Asta, Iani Vladimir, Moan Johan, Clearance mechanism of protoporphyrin IX from mouse skin after application of 5-aminolevulinic acid, Photodiagnosis and Photodynamic Therapy, 10, 4, 2013. Crossref
-
Valdés Pablo A., Samkoe Kimberley, O’Hara Julia A., Roberts David W., Paulsen Keith D., Pogue Brian W., Deferoxamine Iron Chelation Increases δ-Aminolevulinic Acid Induced Protoporphyrin IX in Xenograft Glioma Model, Photochemistry and Photobiology, 86, 2, 2010. Crossref
-
Xia Yumin, Huang Yingying, Lin Longde, Liu Xiaoming, Jiang Shan, Xiong Layuan, A comparative study on the enhancement efficacy of specific and non-specific iron chelators for protoporphyrin IX production and photosensitization in HaCat cells, Journal of Huazhong University of Science and Technology [Medical Sciences], 29, 6, 2009. Crossref
-
Yang Jiabin, Xia Yumin, Liu Xiaoming, Jiang Shan, Xiong Layuan, Desferrioxamine shows different potentials for enhancing 5-aminolaevulinic acid-based photodynamic therapy in several cutaneous cell lines, Lasers in Medical Science, 25, 2, 2010. Crossref
-
Tyrrell Jessica S., Campbell Sandra M., Curnow Alison, The relationship between protoporphyrin IX photobleaching during real-time dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) and subsequent clinical outcome, Lasers in Surgery and Medicine, 42, 7, 2010. Crossref
-
Ba Lalla Aicha, Doering Mandy, Burkholz Torsten, Jacob Claus, Metal trafficking: from maintaining the metal homeostasis to future drug design, Metallomics, 1, 4, 2009. Crossref
-
Tyrrell J.S., Morton C., Campbell S.M., Curnow A., Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites, British Journal of Dermatology, 164, 6, 2011. Crossref
-
Choudhary Sonal, Tang Jennifer, Elsaie Mohamed L., Nouri Keyvan, Lasers in the Treatment of Nonmelanoma Skin Cancer, Dermatologic Surgery, 37, 4, 2011. Crossref
-
Blake Emma, Allen James, Curnow Alison, An In Vitro Comparison of the Effects of the Iron-Chelating Agents, CP94 and Dexrazoxane, on Protoporphyrin IX Accumulation for Photodynamic Therapy and/or Fluorescence Guided Resection, Photochemistry and Photobiology, 87, 6, 2011. Crossref
-
Dogra Yuktee, Ferguson Daniel C.J., Dodd Nicholas J.F., Smerdon Gary R., Curnow Alison, Winyard Paul G., The hydroxypyridinone iron chelator CP94 increases methyl-aminolevulinate-based photodynamic cell killing by increasing the generation of reactive oxygen species, Redox Biology, 9, 2016. Crossref
-
Curnow Alison, Perry Alexis, Wood Mark, Improving in vitro photodynamic therapy through the development of a novel iron chelating aminolaevulinic acid prodrug, Photodiagnosis and Photodynamic Therapy, 25, 2019. Crossref
-
Elenbaas Jared S., Maitra Dhiman, Liu Yang, Lentz Stephen I., Nelson Bradley, Hoenerhoff Mark J., Shavit Jordan A., Omary M. Bishr, A precursor‐inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress, The FASEB Journal, 30, 5, 2016. Crossref
-
Anayo Lizette, Magnussen Anette, Perry Alexis, Wood Mark, Curnow Alison, An experimental investigation of a novel iron chelating protoporphyrin IX prodrug for the enhancement of photodynamic therapy, Lasers in Surgery and Medicine, 50, 5, 2018. Crossref
-
Palasuberniam Pratheeba, Kraus Daniel, Mansi Matthew, Braun Alexander, Howley Richard, Myers Kenneth A., Chen Bin, Ferrochelatase Deficiency Abrogated the Enhancement of Aminolevulinic Acid‐mediated ProtoporphyrinIXby Iron Chelator Deferoxamine, Photochemistry and Photobiology, 2019. Crossref
-
Qin Jiaqi, Zhou Ce, Zhu Mengqi, Shi Shurui, Zhang Lianyun, Zhao Yanhong, Li Changyi, Wang Yinsong, Wang Yue, Iron chelation promotes 5-aminolaevulinic acid-based photodynamic therapy against oral tongue squamous cell carcinoma, Photodiagnosis and Photodynamic Therapy, 31, 2020. Crossref
-
Di Venosa Gabriela, Vallecorsa Pablo, Giuntini Francesca, Mamone Leandro, Batlle Alcira, Vanzuli Silvia, Juarranz Angeles, MacRobert Alexander J., Eggleston Ian M., Casas Adriana, The Use of Dipeptide Derivatives of 5-Aminolaevulinic Acid Promotes Their Entry to Tumor Cells and Improves Tumor Selectivity of Photodynamic Therapy, Molecular Cancer Therapeutics, 14, 2, 2015. Crossref
-
Howley Richard, Mansi Matthew, Shinde Janhavi, Restrepo Juliana, Chen Bin, Analysis of Renal Cell Carcinoma Cell Response to the Enhancement of 5‐aminolevulinic Acid‐mediated Protoporphyrin IX Fluorescence by Iron Chelator Deferoxamine 1 , Photochemistry and Photobiology, 2022. Crossref
-
Reburn Charlotte, Anayo Lizette, Magnussen Anette, Perry Alexis, Wood Mark, Curnow Alison, Hasan Tayyaba, Experimental findings utilising a new iron chelating ALA prodrug to enhance protoporphyrin IX-induced photodynamic therapy , 17th International Photodynamic Association World Congress , 2019. Crossref