RT Journal Article ID 70cda4316e885081 A1 Imbalzano, Anthony N. T1 Energy-Dependent Chromatin Remodelers: Complex Complexes and Their Components JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 1998 FD 1998-12-20 VO 8 IS 3-4 SP 225 OP 255 K1 SWI/SNF K1 RSC K1 NURF K1 CHRAC K1 ACF K1 nucleosome. AB Chromatin structure is dynamically regulated such that it can be modified by a number of factors in response to a variety of signals. One class of factors that can mediate changes in chromatin structure is the ATP-dependent nucleosome remodeling complexes. Genetic and biochemical evidence supports the idea that a family of related multisubunit complexes hydrolyzes ATP in order to facilitate the rearrangement of chromatin structure. These complexes are conserved from yeast to mammals and apparently have diverse functions in modifying chromatin structure; ATP-dependent chromatin remodelers have been implicated in nucleosome deposition, nucleosome assembly, and disruption of nucleosome structure to facilitate transcriptional activation. In addition, individual components of these complexes have been linked to control of cell growth, cell cycle regulation, development, and differentiation, and they may also be targets for viral regulatory proteins. The diversity of subunit functions likely relates to effects on chromatin structure, suggesting that the regulation of chromatin structure by ATP-dependent remodelers is important in many different aspects of cellular metabolism. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,5606821668ad4d06,70cda4316e885081.html