RT Journal Article ID 5d11b27c03b8f781 A1 Qin, Mingming A1 Geng, Yan A1 Lu, Zhenming A1 Xu, Hong-Yu A1 Shi, Jin-Song A1 Xu, Xin A1 Xu, Zheng-Hong T1 Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis JF International Journal of Medicinal Mushrooms JO IJM YR 2016 FD 2016-06-09 VO 18 IS 3 SP 227 OP 234 K1 medicinal mushrooms K1 inflammatory bowel disease K1 ulcerative colitis K1 anti-inflammatory K1 inflammatory mediators K1 Hericeum erinaceus AB This study investigated the anti-inflammatory activity of ethanol extracts of Hericium erinaceus in the inflammatory bowel disease (IBD) model. Twenty C57BL/6 mice were exposed to 2% (w/v) dextran sulfate sodium (DSS) in their drinking water for 7 d to induce acute intestinal inflammation. Orally administrated ethanol extract of H. erinaceus (HEEE) (250 mg/kg/d and 500 mg/kg/d body weight) could significantly (P < 0.05) improve body weight and colon length and decreased the intestinal bleeding of DSS-treated mice compared with DSS-treated mice not given HEEE. HEEE markedly reduced DSS-induced myeloperoxidase accumulation in colon tissues, attenuated histological change in the neutrophils and lymphocyte infiltration, and protected the mucosal epithelium. Mechanistically, HEEE ameliorated colitis not only by suppressing the production of inflammatory mediators including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in colon tissues but also by adjusting the production of nitric oxide, malondialdehyde, and superoxide dismutase in serum to suppress the oxidative stress. These results suggest that HEEE can be applied as a protective agent in the treatment of IBDs. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,23ce65314f371f4f,5d11b27c03b8f781.html