RT Journal Article
ID 5d11b27c03b8f781
A1 Qin, Mingming
A1 Geng, Yan
A1 Lu, Zhenming
A1 Xu, Hong-Yu
A1 Shi, Jin-Song
A1 Xu, Xin
A1 Xu, Zheng-Hong
T1 Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2016
FD 2016-06-09
VO 18
IS 3
SP 227
OP 234
K1 medicinal mushrooms
K1 inflammatory bowel disease
K1 ulcerative colitis
K1 anti-inflammatory
K1 inflammatory mediators
K1 Hericeum erinaceus
AB This study investigated the anti-inflammatory activity of ethanol extracts of Hericium erinaceus in the inflammatory bowel disease (IBD) model. Twenty C57BL/6 mice were exposed to 2% (w/v) dextran sulfate sodium (DSS) in their drinking water for 7 d to induce acute intestinal inflammation. Orally administrated ethanol extract of H. erinaceus (HEEE) (250 mg/kg/d and 500 mg/kg/d body weight) could significantly (P < 0.05) improve body weight and colon length and decreased the intestinal bleeding of DSS-treated mice compared with DSS-treated mice not given HEEE. HEEE markedly reduced DSS-induced myeloperoxidase accumulation in colon tissues, attenuated histological change in the neutrophils and lymphocyte infiltration, and protected the mucosal epithelium. Mechanistically, HEEE ameliorated colitis not only by suppressing the production of inflammatory mediators including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in colon tissues but also by adjusting the production of nitric oxide, malondialdehyde, and superoxide dismutase in serum to suppress the oxidative stress. These results suggest that HEEE can be applied as a protective agent in the treatment of IBDs.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,23ce65314f371f4f,5d11b27c03b8f781.html