RT Journal Article ID 5c025bf8663b32b1 A1 Weaver, David T. T1 Regulation and Repair of Double-Strand DNA Breaks JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 1996 FD 1996-12-20 VO 6 IS 4 SP 345 OP 375 K1 DNA double-strand break repair K1 Ku K1 DNA-dependent protein kinase K1 ionizing radiation K1 V(D)J recombination. AB Double-strand break (DSB) repair in mammalian cells involves the DNA-dependent protein kinase (DNA-PK). DNA-PK is composed of three subunits, a catalytic kinase subunit (DNA-PKcs) mutated in the mouse scid complementation group and the Ku heterodimer. Ku-deficient and DNA-PKcs-deficient cell lines and an animal model have illuminated important features of the DSB repair pathway. Additional factors relevant to several essential functions of DNA replication may point to some overlap between DNA synthesis and DNA repair in eukaryotes. The DNA-PK complex may have broader functions based on its possible involvement in transcriptional regulation and cell cycle checkpoints. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,53a9db3721e198c5,5c025bf8663b32b1.html