RT Journal Article ID 5ba3b3f80fa91418 A1 Liu, Kun A1 Wang, Jun-Li A1 Zhao, Le A1 Wang, Qian T1 Anticancer and Antimicrobial Activities and Chemical Composition of the Birch Mazegill Mushroom Lenzites betulina (Higher Basidiomycetes) JF International Journal of Medicinal Mushrooms JO IJM YR 2014 FD 2014-07-30 VO 16 IS 4 SP 327 OP 337 K1 medicinal mushrooms K1 Lenzites betulina K1 anticancer activity K1 antibiotic activity K1 chemical composition AB The anticancer properties, antibiotic activity, and chemical composition of Lenzites betulina ethanol extract (EE) were evaluated. Eight compounds including 5 sterols were isolated from L. betulina, and 7 compounds were isolated from L. betulina for the first time. The EE displayed strong anticancer activity against tumor cell line MDA-MB-231, with a half maximal inhibitory concentration of 51.46 μg/mL, and there was 83.15% inhibition at a concentration of 200 μg/mL (MTT assay). The antimicrobial activity of the EE was evaluated against 6 microorganisms−Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Fusarium graminearum, Gibberella zeae, and Cercosporella albo-maculans−and the EE showed moderate antibiotic activity. These results suggest that L. betulina could be a good anticancer and antibiotic agent. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,4c99b516238143af,5ba3b3f80fa91418.html