RT Journal Article ID 56326dc302a0463f A1 Mundada, Veenu A1 Patel, Mitali A1 Sawant, Krutika T1 Submicron Emulsions and Their Applications in Oral Delivery JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2016 FD 2016-10-21 VO 33 IS 3 SP 265 OP 308 K1 submicron emulsions K1 microemulsion K1 nanoemulsion K1 self emulsifying drug delivery system K1 oral bioavailability K1 lymphatic targeting K1 P-gp inhibition AB A "submicron emulsion" is an isotropic mixture of drug, lipids, and surfactants, usually with hydrophilic cosolvents and with droplet diameters ranging from 10 to 500 nm. Submicron emulsions are of increasing interest in medicine due to their kinetic stability, high solubilizing capacity, and tiny globule size. Because of these properties, they have been applied in various fields, such as personal care, cosmetics, health care, pharmaceuticals, and agrochemicals. Submicron emulsions are by far the most advanced nanoparticulate systems for the systemic delivery of biologically active agents for controlled drug delivery and targeting. They are designed mainly for pharmaceutical formulations suitable for various routes of administration like parenteral, ocular, transdermal, and oral. This review article describes the marked potential of submicron emulsions for oral drug delivery owing to their numerous advantages like reduced first pass metabolism, inhibition of P-glycoprotein efflux system, and enhanced absorption via intestinal lymphatic pathway. To overcome the limitations of liquid dosage forms, submicron emulsions can be formulated into solid dosage forms such as solid self-emulsifying systems. This article covers various types of submicron emulsions like microemulsion, nanoemulsion, and self-emulsifying drug delivery system (SEDDS), and their potential pharmaceutical applications in oral delivery with emphasis on their advantages, limitations, and advancements. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,2a76b9041f3d17be,56326dc302a0463f.html