RT Journal Article ID 4e629c13281aa009 A1 Lozano, Francisco A1 Simarro, Maria A1 Calvo, Javier A1 Vila, Josep M. A1 Padilla, Olga A1 Bowen, Michael A. A1 Campbell, Kerry S. T1 CD5 Signal Transduction: Positive or Negative Modulation of Antigen Receptor Signaling JF Critical Reviews™ in Immunology JO CRI YR 2000 FD 2000-08-01 VO 20 IS 4 OP 12 AB The CD5 lymphocyte surface glycoprotein is a coreceptor involved in the modulation of antigen-specific receptor-mediated activation and differentiation signals. Although first considered a costimulatory molecule in mature peripheral T cells, recent studies of CD5−/− mice have opened the possibility that CD5 may also mediate inhibitory signals that attenuate TCR/CD3- and BCR-mediated triggering in thymocytes and a subgroup of B cells (B-1a cells), respectively. The ultimate molecular basis for these differential modulatory properties of CD5, depending on the context of lymphocyte subset and differentiation stage, are presently unknown and are an issue of current intensive investigation. Here, we review recent reports, both contradictory and complementary, focused on CD5-mediated molecular intracellular signaling events that could provide the basis for its immunomodulatory properties. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,7a65812e6e1d78de,4e629c13281aa009.html