RT Journal Article
ID 49b6bde944ede8be
A1 Lemieszek, Marta Kinga
A1 Nunes, Fernando Herminio Ferreira Milheiro 
A1 Sawa-Wejksza, Katarzyna 
A1 Rzeski, Wojciech
T1 A King Bolete, <i>Boletus edulis</i> (Agaricomycetes), RNA Fraction Stimulates Proliferation and Cytotoxicity of Natural Killer Cells Against Myelogenous Leukemia Cells
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2017
FD 2017-06-07
VO 19
IS 4
SP 347
OP 353
K1 <i>Boletus edulis</i>
K1 immunomodulation
K1 medicinal mushrooms
K1 natural killer cells
K1 ribonucleic acid
AB Numerous studies indicate the crucial role of natural killer (NK) cells in the prevention of tumor growth and inhibition of their metastasis, which suggests the possibility of their use in cancer treatment. This therapeutic strategy required finding a selective NK cell stimulator that, upon administration, did not disturb organism homeostasis, unlike natural activators (interleukin-2 or interleukin-12). Because the majority of anticancer agents derived from Basidiomycetes are able to stimulate lymphocytes, we describe the influence of <i>Boletus edulis</i> RNA on
a human NK cell line (NK92). Our studies showed that a <i>B. edulis</i> RNA fraction was not toxic against NK92 cells.
Furthermore, the tested fraction significantly stimulated NK92 cell proliferation and their cytotoxicity against tumor
cells. We demonstrate here, to our knowledge for the first time, that <i>B. edulis</i> RNA enhances NK cell activity and possesses immunomodulatory potential.

PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,7e712f4f2518a7dc,49b6bde944ede8be.html