RT Journal Article
ID 4628dda833d40295
A1 zhu, mei
A1 Bai, Xue 
T1 Association of LEPR Gln223Arg Polymorphism with Obstructive Sleep Apnea Syndrome: A Meta-Analysis
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2019
FD 2019-04-10
VO 29
IS 2
SP 171
OP 176
K1 OSAHS
K1 LEPR gene
K1 genetic variant
K1 meta-analysis
AB Previous studies examining the association of leptin receptor (LEPR) Gln223Arg polymorphism with obstructive sleep apnea-hypopnea syndrome (OSAHS) risk have yielded controversial outcomes. We aimed to clarify whether LEPR Gln223Arg polymorphism was critically involved in the development of OSAHS. We thoroughly searched PubMed as well as CNKI datasets for collection of relevant studies, followed by analysis of odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Of the seven case-control studies we enrolled, there was insignificant correlation of the LEPR Gln223Arg polymorphism with OSAHS risk. However, subgroup analysis by Newcastle-Ottawa scale (NOS) scores revealed that, LEPR Gln223Arg polymorphism was significantly related to OSAHS risk in high-quality studies. In addition, we found no publication bias. Our findings suggest that LEPR Gln223Arg polymorphism might contribute to the risk of OSAHS. Well-designed studies with more subjects are needed for further validation of these results.

PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,5cb2c8373871e669,4628dda833d40295.html