RT Journal Article ID 25b8e9a24ec08a0c A1 Du, Peng A1 O'Grady, Greg A1 Davidson, John B. A1 Cheng, Leo K. A1 Pullan, Andrew J. T1 Multiscale Modeling of Gastrointestinal Electrophysiology and Experimental Validation JF Critical Reviews™ in Biomedical Engineering JO CRB YR 2010 FD 2010-11-30 VO 38 IS 3 SP 225 OP 254 K1 slow waves K1 cell models K1 continuum models K1 forward models K1 high-resolution mapping K1 EGG K1 ICCs K1 interstitial cells of Cajal AB Normal gastrointestinal (GI) motility results from the coordinated interplay of multiple cooperating mechanisms, both intrinsic and extrinsic to the GI tract. A fundamental component of this activity is an omnipresent electrical activity termed slow waves, which is generated and propagated by the interstitial cells of Cajal (ICCs). The role of ICC loss and network degradation in GI motility disorders is a significant area of ongoing research. This review examines recent progress in the multiscale modeling framework for effectively integrating a vast range of experimental data in GI electrophysiology, and outlines the prospect of how modeling can provide new insights into GI function in health and disease. The review begins with an overview of the GI tract and its electrophysiology, and then focuses on recent work on modeling GI electrical activity, spanning from cell to body biophysical scales. Mathematical cell models of the ICCs and smooth muscle cell are presented. The continuum framework of monodomain and bidomain models for tissue and organ models are then considered, and the forward techniques used to model the resultant body surface potential and magnetic field are discussed. The review then outlines recent progress in experimental support and validation of modeling, and concludes with a discussion on potential future research directions in this field. PB Begell House LK https://www.dl.begellhouse.com/journals/4b27cbfc562e21b8,4b26e27c6af6b2f3,25b8e9a24ec08a0c.html