RT Journal Article ID 221887df0cec0bf3 A1 Zhang, Xue-ying A1 Zheng, Lian-wen A1 Li, Chun-jin A1 Xu, Ying A1 Zhou, Xu A1 Fu, Lu-lu A1 Li, Dan-dan A1 Sun, Li-ting A1 Zhang, Di A1 Cui, Man-hua T1 Dysregulated Expression of Long Noncoding RNAs in Endometriosis JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2019 FD 2019-04-10 VO 29 IS 2 SP 113 OP 121 K1 endometriosis K1 diagnosis K1 lncRNA K1 biomarker K1 gene expression AB Endometriosis is a common debilitating gynecologic disease. Almost 10% of reproductive-age women are affected by this disease; they commonly suffer pelvic pain and/or infertility. Early diagnosis of this multifactorial disease remains difficult because its etiology is not clear and the early symptoms are nonspecific. In addition, many reproductive-age women are unwilling to undergo invasive laparoscopic surgery because of the possibility of decreasing fertility. Thus, identifying biomarkers for the early diagnosis of endometriosis a key focus of current research. Long noncoding RNAs (lncRNAs) are a class of noncoding transcripts that have length of > 200 nucleotides and lack protein-coding ability but still influence gene expression in various ways. With advances in genome-wide analysis, researchers have determined that lncRNAs play an important role in many human diseases, particularly tumors. Moreover, the role of lncRNAs in the pathogenesis of endometriosis has been continually recognized. In this review, we discuss the status of current research on dysregulated lncRNAs and their roles in the pathogenesis of endometriosis. We aim to stimulate new investigations toward the identification of lncRNAs as biomarkers for the early diagnosis and therapy of this long-term gynecological disease. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,5cb2c8373871e669,221887df0cec0bf3.html