RT Journal Article ID 1862ff3a453fe1e1 A1 Zhang, Jia A1 Li, Min A1 Yang, Ya A1 Yan, Yan A1 Li, Junhai A1 Qu, Jingkun A1 Wang, Jiansheng T1 NPR-A: A Therapeutic Target in Inflammation and Cancer JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2015 FD 2015-03-12 VO 25 IS 1 SP 41 OP 46 K1 natriuretic peptide receptor A K1 inflammation K1 cancer AB Natriuretic peptide receptor A (NPR-A) is the receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). NPR-A plays critical physiological and pathophysiological roles in several target cell and tissue system processes, such as cell growth, apoptosis, proliferation, and inflammation. Accumulating data demonstrate that NPR-A is involved in immune and inflammatory reactions and is a potential target in inflammation treatment. It is expressed in various cancer cells and is important for tumor growth. A recent study indicated that NPR-A signaling can regulate stem cell recruitment and angiogenesis. This signaling can serve as a model for studying the linkage between inflammation and tumorigenesis. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,4abcfae40adc6398,1862ff3a453fe1e1.html