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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Anticancer and Hypoglycemic Effects of Polysaccharides in Edible and Medicinal Maitake Mushroom [Grifola frondosa (Dicks.: Fr.) S. F. Gray]

巻 4, 発行 3, 2002, 11 pages
DOI: 10.1615/IntJMedMushr.v4.i3.10
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要約

An investigation was carried out on the possible anticancer activity and hypoglycemic action of bioactive polysaccharides of Higher Basidiomycetes maitake mushroom [Grifola frondosa (Dicks.: Fr.) S. F. Gray], namely, D-fraction and SX-fraction, on human prostate cancer PC-3 cells in vitro and type 2 diabetic patients. D-fraction at і480 mg/mL was highly cytotoxic to prostatic cancer PC-3 cells, inducing nearly complete cell death (>95%) in 24 hours. The combination of a low concentration (60 [mg/mL) of D-fraction (with no cytotoxic effect) and vitamin С (200 mM) was also found to be as effective as 480 mg/mL D-fraction alone, suggesting a synergistic potentiation of D-fraction with vitamin C. An anticancer agent carmustine (BCNU), capable of inducing a -50% reduction in cell viability by itself (50 mM), then showed its enhanced cytotoxicity with D-fraction (60 mg/mL), resulting in a ~90% cell viability reduction. In clinical studies on hypoglycemic effect of SX-fraction, 5 patients with type 2 diabetes under oral medications demonstrated improved glycemic levels with G. frondosa polysacchande caplets (MFCs) containing active SX-fraction. One patient showed complete glycemic control with MFCs and is currently free of medications, whereas others showed over 30% decline in their serum glucose levels with MFCs in 2 to 4 weeks. Therefore, polysaccharides of G. frondosa may have therapeutic implications in the effective treatments of prostate cancer (anticancer activity) and type 2 diabetes (hypoglycemic action).

によって引用された
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