年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Analysis of the Titer and Reactivity of Antibody/ies Against Fungal Cell Wall β-Glucans in Human Sera
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要約
The aim of this work was to characterize an antibody response to β-glucan (BG), a major component of the fungal cell wall, at each isotype in human sera. The titer and reactivity of the anti-human BG antibody were examined using enzyme-linked immunosorbant assay plates coated with Candida soluble cell wall β-glucan as a standard antigen. The antibody was detected using anti-human immunoglobulin (Ig) G, IgM, and IgA. Its major class was IgG in all subjects. The antibody titer varied significantly. The anti-BG antibody showed greater reactivity to β-glucans derived from pathogenic fungi than monoglycosyl-branched β-glucans derived from mycelia culture medium. In addition, it was suggested that the anti-BG IgM antibody was bound relatively strongly to the β1,3-glucan backbone and the anti-BG IgG antibody to β1,6-glucan. The anti-BG antibody plays a variety of roles, according to class, in the host's response to fungi. We propose a new index of human response to β-glucan that effects the understanding of the response to β-glucan in humans.
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Chan Anissa S. H., Jonas Adria Bykowski, Qiu Xiaohong, Ottoson Nadine R., Walsh Richard M., Gorden Keith B, Harrison Ben, Maimonis Peter J., Leonardo Steven M., Ertelt Kathleen E., Danielson Michael E., Michel Kyle S., Nelson Mariana, Graff Jeremy R., Patchen Myra L., Bose Nandita, Lee Bok-Luel, Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation, PLOS ONE, 11, 11, 2016. Crossref
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Ohno Naohito, Fungal Polysaccharides, in Comprehensive Glycoscience, 2021. Crossref
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