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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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The Immunomodulatory Activity of Polysaccharides from the Medicinal Mushroom Amauroderma rude (Agaricomycetes) Is Mediated via the iNOS and PLA2-AA Pathways

巻 21, 発行 8, 2019, pp. 793-804
DOI: 10.1615/IntJMedMushrooms.2019031543
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要約

Our earlier work indicated that the polysaccharides of Amauroderma rude (AR) appear to have an effect on immunoregulation. However, the pathways are not clear. In this paper, we discuss the immunomodulatory mechanisms of A. rude to provide a scientific basis for its possible use as a food. Amauroderma rude increased the expression of iNOS and P38 in the Raw246.7 cell line. When the AR concentration reached 150 μg/mL, the expressions of iNOS and P38 increased 23.0% and 191.7%, respectively. When the AR concentrations were 50 μg/mL, the concentrations of cytokines IL-2, TNF-α, and IFN-γ were 33.65 pg/mL, 12.53 pg/mL and 42.56 pg/mL. When AR reached 200 μg/mL, the lgA and lgM levels were 0.73 μg/mL and 1.5 μg/mL. When AR reached 400 μg/mL, the lgG level reached 1.65 μg/mL by ELISA assay. When 4.8 mg AR were orally administered, IL-2, TNF-α, IFN-γ, PGE2, and LTB4 increased dramatically, to 0.17 pg/mL, 0.16 pg/mL, 0.15 pg/mL, 30.71 pg/mL, and 18.68 pg/mL, respectively. The concentrations of lgA, lgM, and lgG, AA, and PLA2 also increased significantly to 2.62 pg/mL, 2.14 pg/mL, 2.06 pg/mL, 5.23 μg/mL and 3.68 ng/mL, respectively. With 4.8 mg AR p.o., iNOS protein expression increased 16.8% and P38 increased 234.0%. These results indicate that A. rude polysaccharides stimulate cytokine production and activate the iNOS, PLA2-AA, and MAPK pathways during the immunomodulatory process.

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によって引用された
  1. Zhang Shaojie, Zhang Qi, An Lijun, Zhang Jiaojiao, Li Zhengguo, Zhang Jie, Li Yuhao, Tuerhong Muhetaer, Ohizumi Yasushi, Jin Jin, Xu Jing, Guo Yuanqiang, A fructan from Anemarrhena asphodeloides Bunge showing neuroprotective and immunoregulatory effects, Carbohydrate Polymers, 229, 2020. Crossref

  2. Zhou Ting, Jiang Yueming, Wen Lingrong, Yang Bao, Characterization of polysaccharide structure in Citrus reticulate ‘Chachi’ peel during storage and their bioactivity, Carbohydrate Research, 508, 2021. Crossref

  3. Jose Anju Alphonsa, Hazeena Sulfath Hakkim, Lakshmi Nair M., B Arun K., Madhavan Aravind, Sirohi Ranjna, Tarafdar Ayon, Sindhu Raveendran, Awasthi Mukesh Kumar, Pandey Ashok, Binod Parameswaran, Bacterial biopolymers: From production to applications in biomedicine, Sustainable Chemistry and Pharmacy, 25, 2022. Crossref

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