年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
Indexed in
Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Ameliorates Nonspatial Learning and Memory Deficits in Rats with Hypercholesterolemia and Alzheimer's Disease
要約
Alzheimer's disease (AD) is the leading neurodegenerative disorder affecting memory and learning of aged people. Hypercholesterolemia had been implicated as one of the stark hallmarks of AD. Recent AD control guidelines have suggested lifestyle modification to slow down the progression of AD. In this regard, medicinal mushroom Ganoderma lucidum seems apt. In the present study, hot water extract of G. lucidum (200 mg/kg body weight) was fed to the hypercholesterolemic and AD model rats for 8 weeks. Nonspatial memory and learning abilities of the model animals was assessed using novel object recognition (NOR) test, rotarod test, and locomotor/open-field test. Then, the animals were sacrificed and transmission electron micrograph (TEM) view of the hippocampal neurons was assessed. In all the nonspatial memory and learning tests, the G. lucidum HWE fed rats performed better indicating improved memory and learning abilities. TEM view showed regular arrangement of the neurons in the G. lucidum HWE fed rats compared with those of the deranged arrangement of the AD rats. G. lucidum might have aided in restoring the memory and learning abilities of the AD model animals through maintaining neuronal structure and function. Thus, G. lucidum could be suggested as a medicotherapeutic agent against AD.
-
Yang Z, Slavin MJ, Sachdev PS. Dementia in the oldest old. Nat Rev Neurol. 2013;9(7):382-93.
-
Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med. 2016;8(6):595-608.
-
Stampfer MJ. Cardiovascular disease and Alzheimer's disease: Common links. J Int Med. 2006;260(3):211-23.
-
Sierra S, Ramos MC, Molina P, Esteo C, Vazquez JA, Burgos JS. Statins as neuroprotectants: A comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death. J Alzheimers Dis. 2011;23(2):307-18.
-
Wang MF, Chan YC, Wu CL, Wong YC, Hosoda K, Yamamoto S. Effects of Ganoderma on aging and learning and memory ability in senescence accelerated mice. Int Congr Ser. 2004;1260:399-404.
-
Pinweha S, Wanikiat P, Sanvarinda Y, Supavilai P. The signaling cascades of Ganoderma lucidum extracts in stimulating non-amyloidogenic protein secretion in human neuroblastoma SH-SY5Y cell lines. Neurosci Lett. 2008;448(1):62-66.
-
Lai CSW, Yu MS, Yuen WH, So KF, Zee SY, Chang RCC. Antagonizing P-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum. Brain Res. 2008;1190:215-24.
-
Soccol CR, Bissoqui LY, Rodrigues C, Rubel R, Sella SRBR, Leifa F, de Souza V, Luciana P, Soccol VT. Pharmacological properties of biocompounds from spores of the lingzhi or reishi medicinal mushroom Ganoderma lucidum (Agaricomycetes): A review. Int J Med Mushrooms. 2016;18(9):757-67.
-
Rahman MA, Abdullah N, Aminudin N. Evaluation of the antioxidative and hypo-cholesterolemic effects of lingzhi or reishi medicinal mushroom, Ganoderma lucidum (Agaricomycetes), in ameliorating cardiovascular disease. Int J Med Mushrooms. 2018;20(10):961-9.
-
Rahman MA, Hossain S, Abdullah N, Aminudin N. Brain proteomics links oxidative stress with metabolic and cellular stress response proteins in behavioral alteration of Alzheimer's disease model rats. AIMS Neurosci. 2019;6(4):299-315.
-
Rahman MA, Hossain S, Abdullah N, Aminudin N. Ganoderma lucidum (Fr.) P. Karst. ameliorates spatial learning and memory deficits in rats with hypercholesterolemia and Alzheimer's disease. Int J Med Mushrooms. 2020;22(1):93-103.
-
Abdullah MA, Hashimoto M, Katakura M, Matsuzaki K, Hossain S, Shido O. Neuroprotective effect of madecassoside evaluated using amyloid B1-42-mediated in vitro and in vivo Alzheimer's disease models. Intl J Ind Med Plant. 2014;47: 1669-82.
-
Bevins RA, Besheer J. Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'. Nat Protoc. 2006;1(3):1306-11.
-
Buitrago MM, Schulz JB, Dichgans J, Luft AR. Short and long-term motor skill learning in an accelerated rotarod training paradigm. Neurobiol Learn Mem. 2004;81(3):211-6.
-
Shiotsuki H, Yoshimi K, Shimo Y, Funayama M, Takamatsu Y, Ikeda K, Takahashi R, Kitazawa S, Hattori N. A rotarod test for evaluation of motor skill learning. J Neurosci Methods. 2010;189(2):180-5.
-
Broadbent NJ, Squire LR, Clark RE. Spatial memory, recognition memory, and the hippocampus. Proc Natl Acad Sci U S A. 2004;101(40):14515-20.
-
Squire LR, Wixted JT, Clark RE. Recognition memory and the medial temporal lobe: A new perspective. Nat Rev Neurosci. 2007;8:872-83.
-
Lepousez G, Nissant A, Lledo PM. Adult neurogenesis and the future of the rejuvenating brain circuits. Neuron. 2015;86:387-401.
-
Mori K, Obara Y, Moriya T, Inatomi, S, Nakahata N. Effects of Hericium erinaceus on amyloid. BETA.(25-35) peptide-induced learning and memory deficits in mice. Biomed Res. 2011;32(1):67-72.
-
Goh JJ, Manahan-Vaughan D. Spatial object recognition enables endogenous LTD that curtails LTP in the mouse hippocampus. Cereb Cortex. 2013;23(5):1118-25.
-
Cost KT, Williams-Yee ZN, Fustok JN, Dohanich GP. Sex differences in object-in-place memory of adult rats. Behav Neurosci. 2012;126(3):457-64.
-
Silvers JM, Harrod SB, Mactutus CF, Booze RM. Automation of the novel object recognition task for use in adolescent rats. J Neurosci Methods. 2007;166(1):99-103.
-
Morrone CD, Bazzigaluppi P, Beckett TL, Hill ME, Koletar MM, Stefanovic B, McLaurin, J. Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-P attenuation. Brain. 2020;143(1):359-73.
-
Choi YJ, Yang HS, Jo JH, Lee SC, Park TY, Choi BS, Seo KS, Huh CK. Anti-amnesic effect of fermented Ganoderma lucidum water extracts by lactic acid bacteria on scopolamine-Induced memory impairment in rats. Prev Nutr Food Sci. 2015;20(2):126-32.
-
Leow SS, Sekaran SD, Tan YA, Sundram K, Sambanthamurthi R. Oil palm phenolics confer neuroprotective effects involving cognitive and motor functions in mice. Nutr Neurosci. 2013;16(5):207-17.
-
Zhu WW, Liu ZL, Xu HW, Chu WZ, Ye QY, Xie AM, Chen L, Li JR. Effect of the oil from Ganoderma lucidum spores on pathological changes in the substantia nigra and behaviors of MPTP-treated mice. Di Yi Jun Yi Da Xue Xue Bao. 2005;25(6):667-71.
-
Pietropaolo S, Feldon J, Yee BK. Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer's disease. Cogn Affect Behav Neurosci. 2014;14(3):996-1008.
-
Matsuzaki H, Shimizu Y, Iwata N, Kamiuchi S, Suzuki F, Iizuka H, Hibino Y, Okazaki M. Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats. BMC Complement Altern Med. 2013;13:370-5.
-
Khatian N, Aslam M. Effect of Ganoderma lucidum on memory and learning in mice. Clin Phytosci. 2019;5(4):1-6.
-
Aslam M, Ali N. Antidepressant-like activity of ethanol extract of Ganoderma lucidum (Reishi) in Mice. Intl J Med Res Health Sci. 2017;6(5):55-8.
-
Zhou Y, Qu Z, Zeng Y, Lin Y, Li Y, Chung P, Wong R, Hagg U. Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus. Exp Toxicol Pathol. 2012;64(7):673-80.
-
Lai CSW, Yu MS, Yuen WH, So KF, Zee SY, Chang RCC. Antagonizing P-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum. Brain Res. 2008;1190:215-24.
-
Zhao HB, Lin SQ, Liu JH, Lin ZB. Polysaccharide extract isolated from Ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury. J Pharmacol Sci. 2004;95(2):294-8.
-
Dudhgaonkar S, Thyagarajan A, Sliva D. Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. Int Immunopharmacol. 2009;9(11):1272-80.
-
Yongpan H, Bingjin L, Nanhui Y, Xianlin L, Xianglin K, Jun L. Study of Ganoderma lucidum tri-terpenoids protective effect on brain tissue of AD rat model. Korean J Neurotrauma. 2017;13(2):76-84.
-
Arya Chitra, Potential Uses of Mushrooms as Dietary Supplement to Enhance Memory, in Biology, Cultivation and Applications of Mushrooms, 2022. Crossref
-
Gu Shanye, Zhou Ziyi, Zhang Shijie, Cai Yefeng, Advances in Anti-Diabetic Cognitive Dysfunction Effect of Erigeron Breviscapus (Vaniot) Hand-Mazz, Pharmaceuticals, 16, 1, 2022. Crossref