ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i1.10
pages 1-10

Anxiolytic Effects of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) on Ischemia-Induced Anxiety in Rats

Chunjing Zhang
Department of Biochemistry and Molecular Biology, Qiqihar Medical University, Qiqihar Heilongjiang, PR China
Xiulan Gao
Shandong College of Chinese Medicine, Shandong Yantai, PR China
Yan Sun
Department of Clinical Pathogenic Microorganisms, Qiqihar Medical University, Qiqihar Heilongjiang, PR China
Xiaojie Sun
Qiqihar Medical University, Heilongjiang Qiqihar, China
Yanmin Wu
Qiqihar Medical University, Heilongjiang Qiqihar, China
Ying Liu
Heilongjiang Nursing College, Heilongjiang Harbin, China
Haitao Yu
Department of Biochemistry and Molecular Biology, Harbin Medical University, Heilongjiang Harbin; Department of Biology Genetics, Qiqihar Medical University, Qiqihar Heilongjiang, PR China
Guangcheng Cui
Departments of Clinical Psychology, Qiqihar Medical University, Heilongjiang Qiqihar, China

要約

We investigated the anxiolytic effects Agaricus brasiliensis extract (AbSE) on ischemia-induced anxiety using the plus-maze test and the social interaction test. The animals were treated orally with AbSE (4, 8, and 10 mg/kg/d, respectively) for 30 d, followed by middle cerebral artery occlusion-induced cerebral ischemia. Levels of noradrenaline, dopamine, and serotonin in the cerebral cortex of rats, as well as oxidative stress and plasma corticosterone levels were analyzed, respectively. The rota-rod test was carried out to exclude any false positive results in experimental procedures related to anxiety disorders, and the catalepsy test was carried out to investigate whether AbSE induces catalepsy. Our results demonstrate that oral administration of AbSE presented anxiolytic-like effects in the elevated plus-maze test and the social interaction test. Furthermore, AbSE did not induce extrapyramidal symptoms in the catalepsy test. The mechanism underlying the anxiolytic effect of AbSE might be increased brain monoamine levels and plasma corticosterone levels and decreased oxidative stress in cerebral ischemia/reperfusion rats.


Articles with similar content:

Role of Aqueous Extract of the Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), in Avoidance of Haloperidol-lnduced Catalepsy via Oxidative Stress in Rats
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 4
Gaurav Gupta, Rakesh Kumar Sharma, Xiaohong Liu, Mahaveer Singh, Gopala Krishna Chinnaboina, Anurag Mishra
Efficacy of Zinc as a Nutritional Supplement in Ameliorating Chlorpyrifos-Induced Neurotoxicity in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 3
Devinder K. Dhawan, Anshoo Malhotra, Praveen Nair
Restoration of Brain Antioxidant Status by Hydroalcoholic Extract of Mimusops elengi Flowers in Rats Treated With Monosodium Glutamate
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 3
B.S. Thippeswamy, Pandian Nagakannan, B.D. Shivasharan, V.P. Veerapur
Effect of β-amyloid Peptide on Plasmalemmal Calcium Channels in Cultured Hippocampal Neurons
International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 1
Elena P. Kostyuk, Tatyana Yu. Korol, Platon G. Kostyuk
Pharmacological Studies on Certain Mushrooms from China
International Journal of Medicinal Mushrooms, Vol.3, 2001, issue 4
Vincent Eng Choo Ooi