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International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i3.80
pages 281-288

Evaluation of Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al., Aqueous Extract in Mice Challenged with Salmonella enterica Serovar Typhimurium

Elisabete Fantuzzi
Departamento de Produção Vegetal, Centro de Ciências Agrärias, Universidade Federal do Espirito Santo, ES, Brasil
Lucilene Rezende Anastacio
Programa de Pós- Graduação em Saúde do Adulto, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Jacques Robert Nicoli
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Sergio Oliveira de Paula
Departamento de Biologia Geral, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, MG, Brasil
Rosa Maria Esteves Arantes
Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Maria Cristina Dantas Vanetti
Departamento de Microbiologia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, MG, Brasil

要約

This study investigated the effects of Agaricus brasiliensis S. Wasser et al. (= Agaricus blazei Murrill sensu Heinem.) aqueous extract on small intestinal sIgA levels, serum TNF-α, IFN-γ and IL-10 levels, splenic index, bacterial translocation, and histology of small intestine, spleen, and liver from mice orally challenged with 106 CFU of Salmonella enterica serovar Typhimurium (SEST). Splenic index values as well as sIgA, TNF-α, IFN-γ and IL-10 levels were not affected by either A. brasiliensis aqueous extract treatment or by pathogenic challenge. Typical colonies of SEST were recovered from liver, spleen, and mesenteric lymph nodes of challenged animals, but there was no significant difference in this translocation between groups treated or not with A. brasiliensis aqueous extract. Translocation was confirmed by histopathological analysis in mice challenged with SEST, which showed small and diffuse foci of mixed inflammatory infiltrate in hepatic parenchyma. In conclusion, A. brasiliensis aqueous extract as tested in the present study did not influence any of the variables selected to evaluate in vivo its immunomodulatory effect suggested in the literature.


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