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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Antimicrobial and Antitoxical Action of Edible and Medicinal Mushroom Pleurotus ostreatus (Jacq.: Fr.) Kumm. Extracts

巻 4, 発行 2, 2002, 6 pages
DOI: 10.1615/IntJMedMushr.v4.i2.50
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要約

Fourteen strains of Pleurotus ostreatus (Jacq.: Fr.) Kumm. (Agaricales s.l.) were investigated as possible producers of biologically active substances. After submerged cultivation, biologically active materials were isolated as extracts from cultural liquids and mycelia. Extracts were evaporated and dry residue dissolved. Antimicrobial activity was tested by the method of diffusion in agar medium inoculated with microorganisms. Disks saturated with solution were used. All strains manifest antimicrobial activity during submerged cultivation in experiments with extracts; cultural liquids demonstrated only minimal activity, so these strains have low levels of biosynthesis. Extracts of fruit bodies grown on corn were inactive. For the next investigation, one strain of P. ostreatus with the highest levels of biosynthesis was chosen. During submerged cultivation this strain produced two different substances with antibiotic activity, one with high activity against Aspergillus niger INA 00760 and the other with activity against Gram-positive as well as Gram-negative bacteria. Antifungal activity against Aspergillus niger/i> INA 00760, Saccharomyces cerevisiae RIA 259, and Candida albicans INA 00763 in mycelium extracts was not found. Mycelial extract was fractionated and it was shown that antimicrobial substance (or substances) in mycelial extract makes up not more than 1% of dry weight. Investigation of mycelial extract as anticancer and antitoxic drugs was studied in CBA mice. Anticancer action was tested in mice transplanted with Ehrlich’s ascites tumor. Toxic effect (decreasing of body weight and leucopenia) was noted in animals after cyclophosphamide (CP) administration in doses of 100 mg/kg. Extract was administrated daily. The first extract injection was given 2 h after CP administration. A number of leucocytes in peripheral blood were studied after CP treatment, producing a decrease of leucopenia level during this period. According to our data, P. ostreatus extracts produce a decrease of CP hematotoxicity.

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