ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i4.30
pages 357-364

The Agaricoglyceride of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) is Anti-Inflammatory and Reverses Diabetic Glycemia in the Liver of Mice

Haitao Yu
Department of Biochemistry and Molecular Biology, Harbin Medical University, Heilongjiang Harbin; Department of Biology Genetics, Qiqihar Medical University, Qiqihar Heilongjiang, PR China
Chunchao Han
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China
Yan Sun
Department of Clinical Pathogenic Microorganisms, Qiqihar Medical University, Qiqihar Heilongjiang, PR China
Xiaodan Qi
Department of Clinical Biochemistry, Qiqihar Medical University, Qiqihar Heilongjiang, PR China
Yan Shi
Department of Biochemistry and Molecular Biology, Qiqihar Medical University, Qiqihar Heilongjiang, PR China
Xu Gao
Department of Biochemistry and Molecular Biology, Harbin Medical University, Heilongjiang Harbin, People’s Republic of China
Chunjing Zhang
Department of Biochemistry and Molecular Biology, Qiqihar Medical University, Qiqihar Heilongjiang, PR China

要約

The agaricoglyceride is a new fungal secondary metabolite that constitutes esters of chlorinated 4-hydroxy benzoic acid and glycerol. The objective of this study was to explore whether the administration of agaricoglyceride could correct hepatic glycemic metabolism dysfunction by attenuating inflammation in the liver. The effects of agaricoglycerides on tumor necrosis factor-α, interleukin-1β, vascular endothelial growth factor-α, interleukin-17, insulin secretion, adiponectin, leptin, hepatic glycogen, nuclear factor-κB activation, and total antioxidant activity were studied respectively. We demonstrated that administration of agaricoglycerides alleviated glycemic metabolism dysfunction, inflammation, and oxidative stress in mice. These data indicate that agaricoglyceride supplementation could restrain metabolic dysfunction through suppressing the nuclear factor-κB pathway as well as decreasing the levels of inflammatory cytokines and total antioxidant activities.


Articles with similar content:

Turmeric Bioprocessed with Mycelia from the Shiitake Culinary-Medicinal Mushroom Lentinus edodes (Agaricomycetes) Protects Mice Against Salmonellosis
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 4
Sung Phil Kim, Seok Hyun Nam, Mendel Friedman, Sang Jong Lee
Hypoxia-Inducible Factor-lα Increase is an Early and Sensitive Marker of Lung Cells Responding to Benzo[a]Pyrene
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 4
Olga Mavrofrydi , Panagiota Papazafiri
The ROS-NOX Connection in Cancer and Angiogenesis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.18, 2008, issue 1
Christophe Blanchetot, Johannes Boonstra
The Effect of Agaricus brasiliensis and Ganoderma lucidum Medicinal Mushroom Administration on the L-arginine/Nitric Oxide System and Rat Leukocyte Apoptosis in Experimental Type 1 Diabetes Mellitus
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 4
Solomon P. Wasser, Nataliya O. Sybirna, Borys Yurkiv, Eviatar D. Nevo
Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 9
Yoshiyuki Adachi, Daisuke Yamanaka, Toshitsugu Miyazaki, Hisatomi Ito, Yuina Ishimoto, Kentaro Igami, Naohito Ohno, Ken-Ichi Ishibashi