年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
Indexed in
Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats
要約
This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZGDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout the evolution of pregnancy.
-
Yang Hye, Kim Min, Kwon Dae, Kim Da, Zhang Ting, Ha Chulgyu, Park Sunmin, Combination of Aronia, Red Ginseng, Shiitake Mushroom and Nattokinase Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats, Nutrients, 10, 7, 2018. Crossref
-
Laurino Leticia, Viroel Fabia, Caetano Erika, Spim Sara, Pickler Thaisa, Rosa-Castro Raquel, Vasconcelos Edilma, Jozala Angela, Hataka Alessandre, Grotto Denise, Gerenutti Marli, Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus, Nutrients, 11, 11, 2019. Crossref
-
Gulati Vandana, Dass Singh Mansi, Gulati Pankaj, Role of mushrooms in gestational diabetes mellitus, AIMS Medical Science, 6, 1, 2019. Crossref
-
Yang Dengyu, Wang Tiancheng, Long Miao, Li Peng, Quiles Jos L., Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine, Oxidative Medicine and Cellular Longevity, 2020, 2020. Crossref
-
Ingole Ashwini, Kadam Megha P, Dalu Aishwarya P., Kute Shital M, Mange Piyusha R, Theng Vaishali D, Lahane Om R, Nikas Aniket P, Kawal Yash V, Nagrik Shatrughna U., Patil Prashant A., A Review of the Pharmacological Characteristics of Vanillic Acid, Journal of Drug Delivery and Therapeutics, 11, 2-S, 2021. Crossref