ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i3.20
pages 233-249

Heat-Stable Components of Wood Ear Mushroom, Auricularia polytricha (Higher Basidiomycetes), Inhibit In Vitro Activity of Beta Secretase (BACE1)

Louise Bennett
CSIRO Preventative Health Flagship, Animal, Food and Health Sciences, Werribee, Victoria, Australia
Paul Sheean
CSIRO Preventative Health Flagship, Animal, Food and Health Sciences, Werribee, Victoria, Australia
Dimitrios Zabaras
CSIRO Animal, Food and Health Sciences, North Ryde, New South Wales, Australia
Richard Head
CSIRO Preventative Health National Research Flagship, Adelaide, Australia

要約

The consumption of mushrooms has been linked with protection against dementia, including Alzheimer's disease (AD), by several biological pathways including inhibiting beta-site APP-cleaving enzyme (BACE1), which is responsible for releasing toxic β-amyloid peptide in the brain. We have investigated the capacity of several medicinal mushroom species−Auricularia polytricha (wood ear mushroom), Agaricus bisporus (button mushroom), Flammulina velutipes (winter or enoki mushroom), and Lentinus edodes (shiitake mushroom)−in the regulation of BACE1. Mushrooms were subjected to a generic food-compatible processing method to detect process-stable or process-modified products; the effects of processing were interpreted to infer the chemical classes associated with bioactivity. We have shown previously that in addition to enzyme inhibition, in the presence of the BACE1 proenzyme, heteropolymeric species such as heparin can activate BACE1 by modulating access to the catalytic site. We observed both inhibitory and activating components of the various mushrooms. Only BACE1 inhibitory species were detected in unprocessed and processed forms of A. polytricha, whereas the dominant extracted species from A. bisporus, F. velutipes, and L. edodese were activators of BACE1. It is not known whether activating species were masking the presence of inhibitory species in A. bisporus, F. velutipes, and L. edodes. Inhibitory species were attributed to hispidin-derived polyphenols, whereas activating species were attributed to soluble polysaccharides and possibly low-mass Maillard products produced during processing. Larger molecular BACE1-activating species are unlikely to be bioavailable to brain in contrast with possible brain bioavailability of smaller, lipophilic hispidins.


Articles with similar content:

Total Phenolic Content and Antioxidant Activity of Mycelial Extracts from the Medicinal Fungus Paecilomyces hepiali (Ascomycetes)
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 1
Yi Li, Abdessamad Imoulan, Lan Jiang, Wen-Jing Wang, Yi-Jian Yao
The Influence of the Cultivation Conditions on the Chemical Composition of Medicinal Mushrooms Pleurotus ostreatus (Jacq.: Fr.) Kumm. and Lentinus edodes (Berk.) Sing.
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 2
Valentina G. Babitskaya, Victor V. Scherba, Valentina I. Fomina, Vycheslav V. Truchonovec, Nina A. Bisko, Nadezda Yu. Mitropolskaya
Antimelanogenesis and Anti-Inflammatory Activity of Selected Culinary-Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 2
Yee Shin Tan, Hazwani Mat Saad, Kae Shin Sim
Triterpenes and Sterols from Ganoderma australe (Fr.) Pat. (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.2, 2000, issue 4
Nelson Biacchi, Jr., Alexandra Lehmkuhl Gerber, Artur Smania, Jr., Franco Delie Monache, Elza de Fatima Albino Smania
Antioxidant and Immunomodulating Activities of Exo-and Endopolysaccharide Fractions from Submerged Mycelia Cultures of Culinary-Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 3
Karthik Marripudi, Cheang Khoo, Sundar Rao Koyyalamudi, Jong Pil Park, Jin Hee Kim, Sang-Chul Jeong, Chi-Hyun Song, J. Margaret Hughes, Trevor Bailey