ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i1.100
pages 83-95

Wild Edible Mushrooms from Turkey as Possible Anticancer Agents on HepG2 Cells Together with Their Antioxidant and Antimicrobial Properties

Gokhan Sadi
Department of Biology, Karamanoglu Mehmetbey University, Karaman, Turkey
Abdullah Kaya
Department of Biology, Karamanoglu Mehmetbey University, Karaman, Turkey
Hicret Asli Yalcin
Department of Biology, Karamanoglu Mehmetbey University, Karaman, Turkey
Bugrahan Emsen
Department of Biology, Karamanoglu Mehmetbey University, Karaman, Turkey
Aytac Kocabas
Department of Biology, Karamanoglu Mehmetbey University, Karaman, Turkey
Deniz Irtem Kartal
Biochemistry Graduate Programme, Middle East Technical University, Ankara, Turkey
Ahmet Altay
Biochemistry Graduate Programme, Middle East Technical University, Ankara, Turkey

要約

This study was designed to reveal cell growth inhibitory potential of six different edible mushrooms: Ramaria flava, Agrocybe molesta, Volvopluteus gloiocephalus, Lactarius deliciosus, Bovista plumbea, and Tricholoma terreum on HepG2 cells together with their antioxidant and antibacterial power. Methanolic extracts of V gloiocephalus and aqueous extracts of R. flava had the most potential cytotoxic effects over HepG2 cells. The best results for 2,2-diphenyl-1-picrylhydrazyl radical scavenging activities were obtained from both aqueous and methanolic extracts of R. flava. Methanolic extracts of T. terreum (IC50 = 1.62 mg/mL) and aqueous extracts of B. plumbea (IC50 = 0.49 mg/mL) showed maximum metal chelating activity. The highest reducing capacities were observed among the methanolic extracts of R. flava (EC50 = 1.65 mg/mL) and aqueous extracts of B. plumbea (EC50 = 1.71 mg/ mL). High-performance liquid chromatography analysis revealed the presence of many phenolic compounds in macrofungi; gallic acid and p-coumaric acid were the two main phenolics identified in all extracts. Antibacterial studies indicated that all six tested mushrooms showed antibacterial activity on at least three microorganisms. These results indicate that different extracts of the investigated mushrooms have considerable cytotoxic, antioxidant, and antibacterial properties and may be utilized as a promising source of therapeutics.


Articles with similar content:

Comparative Study of Wild Edible Mushrooms as Sources of Antioxidants
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 4
Anna M. Witkowska, Matgorzata E. Zujko, Iwona Mironczuk-Chodakowska
Antioxidant Activities and Bioactive Compound Determination from Caps and Stipes of Specialty Medicinal Mushrooms Calocybe indica and Pleurotus sajor-caju (Higher Basidiomycetes) from India
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 6
Krishna Kant Mishra, Raja Arunkumar, Ramesh Singh Pal
Comparison of Antioxidant and Antiproliferation Activities of Polysaccharides from Eight Species of Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 3
Yangyang Yong, Yifan Gu, Zeliang Wang, Shizhu Zhang, Peiying Chen, Ling Lu
Antimicrobial Activity of Two Wild Mushrooms, Clitocybe alexandri (Gill.) Konrad and Rhizopogon roseolus (Corda) T.M. Fries, Collected in Turkey
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Fadime Yilmaz Ersel, Fatih Kalyoncu, Erbil Kalmis, Husniye Saglam, M. Halil Solak
Antioxidant and Enzyme Inhibitory Activities of Extracts from Wild Mushroom Species from Turkey
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 4
Abdurrahman Aktumsek, Gokhan Zengin, Mehmet Sefa Kocak, Mehmet Cemil Uren, Marcello Locatelli, Halil Gungor, Cengiz Sarikurkcu