年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
Indexed in
Immunomodulatory Activities of Mushroom Glucans and Polysaccharide–Protein Complexes in Animals and Humans (A Review)
要約
This review discusses current information on the ability of extracts from medicinal mushrooms to stimulate or modulate animal and human immune responses. Numerous bioactive polysaccharides or polysaccharide-protein complexes from medicinal mushrooms are described that appear to enhance innate and cell-mediated immune responses and exhibit antitumor activities in animals and humans. Stimulation of host immune defense systems by bioactive polymers from medicinal mushrooms has significant effects on the maturation, differentiation, and proliferation of many kinds of immune cells in the host. Many of these mushroom polymers were reported previously to have immunotherapeutic properties by facilitating growth inhibition and destruction of tumor cells. Recent research has also shown that some of these mushroom-derived polymers may possess direct cytotoxic effects on cancer cells. Although the mechanism of their antitumor actions is still not completely understood, stimulation and modulation of key host immune responses by these mushroom polymers appears central. Recent evidence suggests that mushroom polymers (b-glucans) may trigger the stimulation of many kinds of immune cells in animals and humans by binding to a specific cellular receptor known as complement receptor type 3 or CR3.
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Smiderle Fhernanda R., Olsen Lorena M., Carbonero Elaine R., Baggio Cristiane H., Freitas Cristina S., Marcon Rodrigo, Santos Adair R.S., Gorin Philip A.J., Iacomini Marcello, Anti-inflammatory and analgesic properties in a rodent model of a (1→3),(1→6)-linked β-glucan isolated from Pleurotus pulmonarius, European Journal of Pharmacology, 597, 1-3, 2008. Crossref
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Wasser Solomon P., Current findings, future trends, and unsolved problems in studies of medicinal mushrooms, Applied Microbiology and Biotechnology, 89, 5, 2011. Crossref
-
Morris Humberto J., Lebeque Yamila, Fontaine Roberto, Bermúdez Rosa C., Llauradó Gabriel, Marcos Jane, A note on thein vitromacrophage-stimulating activity of water-soluble extracts from mycelium ofPleurotusspp., Food and Agricultural Immunology, 18, 1, 2007. Crossref
-
Torkelson Carolyn J., Slaton Joel W., Standish Leanna J., Medicinal Mushrooms: A Contemporary Perspective, Seminars in Preventive and Alternative Medicine, 3, 1, 2007. Crossref
-
Matijašević Danka, Pantić Milena, Rašković Božidar, Pavlović Vladimir, Duvnjak Dunja, Sknepnek Aleksandra, Nikšić Miomir, The Antibacterial Activity of Coriolus versicolor Methanol Extract and Its Effect on Ultrastructural Changes of Staphylococcus aureus and Salmonella Enteritidis, Frontiers in Microbiology, 7, 2016. Crossref
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Asatiani Mikheil D., Elisashvili Vladimir, Songulashvili George, Reznick Abraham Z., Wasser Solomon P., Higher Basidiomycetes Mushrooms as a Source Of Antioxidants, in Progress in Mycology, 2010. Crossref
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Ullah Muhammad Irfan, Akhtar Masood, Awais Mian Muhammad, Anwar Muhammad Irfan, Khaliq Kashfa, Evaluation of immunostimulatory and immunotherapeutic effects of tropical mushroom (Lentinus edodes) against eimeriasis in chicken, Tropical Animal Health and Production, 50, 1, 2018. Crossref
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Wang Wenli, Tan Jiaqi, Nima Lamu, Sang Yumei, Cai Xu, Xue Hongkun, Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities, Food Chemistry: X, 15, 2022. Crossref