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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Immunomodulation and Antitumor Activity of a Mushroom Product, Proflamin, Isolated from Flammulina velutipes (W. Curt.: Fr.) Singer (Agaricomycetideae)

巻 9, 発行 2, 2007, pp. 109-122
DOI: 10.1615/IntJMedMushr.v9.i2.20
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要約

Proflamin (PRF), an antitumor agent, is orally effective against the syngeneic tumor in mice and is a biological response modifier obtained from an edible mushroom. It has been isolated from the mycelia of Flammulina velutipes (W. Curt.: Fr.) Singer and is an acidic glycoprotein containing more than 90% protein and less than 10% carbohydrate; its molecular weight is 13,000 ± 4000. PRF greatly increases the lifespan of mice implanted with the syngeneic tumors, B-16 melanoma and adenocarcinoma 755 and inhibits the growth of solid tumors of Sarcoma 180 (S-180) by so-called "host-mediated" antitumor activities. PRF inhibited the growth of S-180 or L1210 leukemia ascite cells in combination with the S-180 solubilized vaccine or glutaraldehyde and Con A-bound L1210 vaccine and showed strong antitumor activity when a combination therapy was given with surgical treatment in mice bearing Meth-A fibrosarcoma (Meth-A). The combination therapy with cryosurgery and PRF was found to abolish the suppression of tumor immunocompetence at 2 weeks after cryosurgery, and it exhibited no toxic actions either in vitro or in vivo. Oral administration of PRF significantly intensified various immunoresponses in tumor-bearing mice, but it was not very effective against the immunity of healthy (non-tumor-bearing) mice. The effective dose range for immunomodulation was rather wide (1−30 mg/kg), and the optimum dose was supposed to be about 10 mg/kg when administered PO, consecutively. These doses were almost the same as those for the treatment of tumors in the mice mentioned above. A protein-bound polysaccharide, EA6, was also isolated from fruit bodies of F. velutipes. Treatment with EA6 after the surgery remarkably inhibited growth of the rechallenged Meth-A solid tumor, and the effect was mediated by CD4+ T cells. Furthermore, EA6 augmented the humoral immunity, cellular immunity, and IL-2 production against Meth-A tumor antigen after surgery.

によって引用された
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  3. Tang Calyn, Hoo Pearl Ching-Xin, Tan Loh Teng-Hern, Pusparajah Priyia, Khan Tahir Mehmood, Lee Learn-Han, Goh Bey-Hing, Chan Kok-Gan, Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties, Frontiers in Pharmacology, 7, 2016. Crossref

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  5. Vetchinkina Elena, Fomin Alexander, Navolokin Nikita, Shirokov Alexander, Proteins and polysaccharides from vegetative mycelium of medicinal basidiomycete Lentinus edodes display cytotoxicity towards human and animal cancer cell lines, International Journal of Biological Macromolecules, 195, 2022. Crossref

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