ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

巻:
巻 22, 2020 巻 21, 2019 巻 20, 2018 巻 19, 2017 巻 18, 2016 巻 17, 2015 巻 16, 2014 巻 15, 2013 巻 14, 2012 巻 13, 2011 巻 12, 2010 巻 11, 2009 巻 10, 2008 巻 9, 2007 巻 8, 2006 巻 7, 2005 巻 6, 2004 巻 5, 2003 巻 4, 2002 巻 3, 2001 巻 2, 2000 巻 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2019030648
pages 443-458

Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Mycelium Aqueous Extract Modulates High-Altitude–Induced Stress

Anuja Bhardwaj
Defence Institute of Physiology and Allied Sciences, DRDO, Lucknow Road, Timarpur, Delhi, India
Priyanka Sharma
Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, India
Jigni Mishra
Defence Institute of Physiology and Allied Sciences, DRDO, Lucknow Road, Timarpur, Delhi, India
Kshipra Misra
Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, India; Defence Institute of Bio-Energy Research, Haldwani 263139, India

要約

Environmental adversities such as high altitudes impair human performance and under such environmental threats, adaptogens tend to enhance physical endurance, mental functions, and nonspecific resistance of the body. Herein, adaptogenic activity of the medicinal mushroom Ganoderma lucidum (mycelium aqueous extract; GLMaq) was evaluated by exposing rats to cold (5°C), hypoxia (428 mm Hg), and a restraint state. GLMaq was administered orally at 50, 100, and 150 mg/kg body weight (bw) and rats were fasted overnight before exposure. After exposure, antioxidant and stress markers (catalase, lactate dehydrogenase, lipid peroxidation, reduced glutathione, and superoxide dismutase levels) were investigated in tissue homogenates (liver, heart, and skeletal muscle) along with hematological parameters. Mitochondrial morphology was observed by transmission electron microscopy in skeletal muscles. Biodistribution study for technetium-99m–labeled GLMaq was determined in mice in blood and major organs (heart, intestine, kidney, liver, lungs, muscle, spleen, and stomach). Antioxidants (ascorbic acid, gallic acid, rutin, and quercetin) were quantified by ultra-performance liquid chromatography. In vitro free radical scavenging activities were also determined. A 100 mg/kg bw dose was found to be relatively effective as measured by time taken to reach rectal temperature (Trec) 23°C; however, the 50 mg/kg bw dose showed significant results as observed from biochemical parameters for liver, heart, and skeletal muscle. The current study suggested the potential use of GLMaq as an adaptogenic agent against high-altitude–induced stress; this is further supported by a wide distribution of technetium-99m radiolabeled G. lucidum mycelium aqueous extract to various organs and protective effects of GLMaq against mitochondrial impairment by maintaining mitochondrial number and morphology.


Articles with similar content:

The Medicinal Cracked-Cap Polypore Mushroom Phellinus rimosus (Higher Basidiomycetes) Attenuates Alloxan-Induced Hyperglycemia and Oxidative Stress in Rats
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 3
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan, Kuttikkadan A. Rony, John Mathew
Medicinal Mushroom Cracked-Cap Polypore, Phellinus rimosus (Higher Basidiomycetes) Attenuates Acute Ethanol-Induced Lipid Peroxidation in Mice
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 11
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan
Trichosanthes dioica Fruit Extract Ameliorates Arsenic-Induced Brain Toxicity in Male Albino Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 2
Sanjib Bhattacharya, Pallab Kanti Haldar
Mitigating Acetaminophen-Induced Hepatotoxicity by Using a Water-Alcohol Extract of Phellinus caryophylli (Agaricomycetes) in a Murine Model
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 4
Cherupally Krishnan Krishnan Nair, Prasad Y. Lamrood, Yogesh Bharat Dalvi, Ruby Varghese
Reduction of Gamma Radiation–Induced Damage by Hydro-Alcoholic Extract of Nardostachys jatamansi
Journal of Environmental Pathology, Toxicology and Oncology, Vol.38, 2019, issue 1
Teeju Majeed, Praseetha R. Nair, Cherupally Krishnan Krishnan Nair, Aditya Menon, Tiju Chacko