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International Journal of Medicinal Mushrooms
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ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i3.60
pages 235-244

Antioxidant, Anti-Inflammatory, and Antitumor Activities of Cultured Mycelia and Fruiting Bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes)

Panavalappil Greeshma
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, India
Korattuvalappil S. Ravikumar
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, India
Mangalathmelathil N. Neethu
Department of Microbiology, St. Mary's College, Thrissur, India
Meera Pandey
Division of Plant Pathology, Indian Institute of Horticultural Research, Bangalore, Karnataka, India
Karattuthodi Fathimathu Zuhara
Department of Life Sciences, University of Calicut, Thenjipalam, Malappuram, India
Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555, Kerala, India

要約

Ethanoic extracts from the fruiting bodies and mycelia of the elm oyster mushroom, Hypsizygus ulmarius, were evaluated for their antioxidant, anti-inflammatory, and antitumor properties. Ethnolic extracts of fruiting body and mycelia showed 88%, 85%, 71%, and 85%, 65%, 70% 2,2-diphenyl-1-picrylhydrazyl, hydroxyl (DPPH) and 2,2'-azinobis (3-ethyl benzothiazolin-6-sulfonic acid) (ABTS) radical-scavenging activities, respectively, at a concentration of 1000 µg/mL. The anti-inflammatory activity was determined using carrageenan- and formalin- induced paw edema models. Diclofenac was used as the standard drug. In both models, the mycelia extract showed higher activity than the fruiting body extract. The antitumor effect of the extracts against Dalton's Lymphoma Ascites cell-line−induced tumors showed significant antitumor activity. Mycochemical analysis confirmed the presence of many pharmacologically active compounds such as phenol, alkaloids, proteins, tannins, and polysaccharides. Among these, polysaccharides and phenolic compounds were present at a higher concentration in both extracts. These compounds might be largely responsible for the mushroom's medicinal properties. The results of this study indicate that H. ulmarius possesses significant antioxidant, anti-inflammatory, and antitumor properties.


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