年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
Indexed in
Review of Biological and Pharmacological Activities of the Endemic Taiwanese Bitter Medicinal Mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (Higher Basidiomycetes)
要約
Antrodia camphorata is an extremely rare fungus native to the forested regions of Taiwan. It is also a traditional Chinese medicine, and Taiwanese aborigines applied it for treating liver diseases and protecting from food and drug intoxication. Scientific studies have demonstrated that A. camphorata crude extracts and pure compounds possess a variety of beneficial functions, such as anti-hypertensive, anti-hyperlipidemic, anti-inflammatory, anti-oxidant, anti-tumor, and immuno-modulatory activities. Recent studies have shown that many of these biological and pharmacological activities can be attributed to various active constituents, including polysaccharides, terpenoids, steroids, lignans, benzoquinone derivatives, benzenoids, and maleic and succinic acid derivatives. A. camphorata has been considered as a novel phytotherapeutic agent. However, detailed mechanistic studies or even clinical trials on A. camphorata are still rare. With the help of modern analytical techniques, it is not surprising that many novel constituents are being identified or fractionated from A. camphorata mycelium and fruiting bodies. This review summarizes the latest published results from A. camphorata research, focusing on the biological and pharmacological activities of the crude extract and known constituents of A. camphorata.
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Boukouvalas John, Albert Vincent, Loach Richard P., Lafleur-Lambert Raphaël, Unified route to asymmetrically substituted butenolide, maleic anhydride, and maleimide constituents of Antrodia camphorata, Tetrahedron, 68, 47, 2012. Crossref
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Shimosato Takeshi, Kanoh Junko, Otani Hajime, Oral administration of a fruiting body extract ofBoletopsis leucomelasenhances intestinal IgA production in LPS-challenged mice, Food and Agricultural Immunology, 25, 4, 2014. Crossref
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De Silva Dilani D., Rapior Sylvie, Sudarman Enge, Stadler Marc, Xu Jianchu, Aisyah Alias S., Hyde Kevin D., Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry, Fungal Diversity, 62, 1, 2013. Crossref
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Zelena Katerina, Eisele Nadine, Berger Ralf G., Escherichia coli as a production host for novel enzymes from basidiomycota, Biotechnology Advances, 32, 8, 2014. Crossref
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Yang Hsin-Ling, Kumar K. J. Senthil, Kuo Ya-Ting, Chang Hebron C., Liao Jiunn-Wang, Hsu Li-Sung, Hseu You-Cheng, Antrodia camphorata induces G1cell-cycle arrest in human premyelocytic leukemia (HL-60) cells and suppresses tumor growth in athymic nude mice, Food Funct., 5, 9, 2014. Crossref
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Lin Chin-Chung, Kumar K.J. Senthil, Liao Jiunn-Wang, Kuo Yueh-Hsiung, Wang Sheng-Yang, Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea ® ), Toxicology Reports, 2, 2015. Crossref
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Lin Yu-Hsing, Senthil Kumar K.J., Gokila Vani M., Liao Jiunn-Wang, Lin Chin-Chung, Kuo Jong-Tar, Wang Sheng-Yang, <i>In vitro </i>and <i>in vivo</i> toxicological assessments of <i>Antrodia cinnamomea</i> health food product (Leader <i>Antrodia cinnamomea</i> Capsule), Fundamental Toxicological Sciences, 3, 5, 2016. Crossref
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Kumar K. J. Senthil, Wang Sheng-Yang, Antioxidant Properties of Antrodia cinnamomea: An Extremely Rare and Coveted Medicinal Mushroom Endemic to Taiwan, in Medicinal Plants and Fungi: Recent Advances in Research and Development, 4, 2017. Crossref
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Lin Chi-Chen, Pan I-Hong, Li Yi-Rong, Pan Yi-Gen, Lin Ming-Kuem, Lu Yi-Huang, Wu Hsin-Chieh, Chu Ching-Liang, Mattei Fabrizio, The Adjuvant Effects of High-Molecule-Weight Polysaccharides Purified from Antrodia cinnamomea on Dendritic Cell Function and DNA Vaccines, PLOS ONE, 10, 2, 2015. Crossref
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Hseu You-Cheng, Chao Yu-Hsien, Lin Kai-Yuan, Way Tzong-Der, Lin Hui-Yi, Thiyagarajan Varadharajan, Yang Hsin-Ling, Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/β-catenin signaling pathways in human colon cancer cells, Journal of Ethnopharmacology, 208, 2017. Crossref
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Phan Chia-Wei, Wang Joon-Keong, Cheah Shiau-Chuen, Naidu Murali, David Pamela, Sabaratnam Vikineswary, A review on the nucleic acid constituents in mushrooms: nucleobases, nucleosides and nucleotides, Critical Reviews in Biotechnology, 38, 5, 2018. Crossref
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Zheng Junping, Jiao Siming, Li Qiongyu, Jia Peiyuan, Yin Heng, Zhao Xiaoming, Du Yuguang, Liu Hongtao, Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation, Molecules, 23, 1, 2017. Crossref
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Huang Hung, Wang San-Lang, Nguyen Van, Kuo Yao-Haur, Isolation and Identification of Potent Antidiabetic Compounds from Antrodia cinnamomea—An Edible Taiwanese Mushroom, Molecules, 23, 11, 2018. Crossref
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You Ren-In, Lee Yi-Pang, Su Ting-Yi, Lin Chi-Chien, Chen Chang-Shan, Chu Ching-Liang, A Benzenoid 4,7-Dimethoxy-5-Methyl-L, 3-Benzodioxole from Antrodia cinnamomea Attenuates Dendritic Cell-Mediated Th2 Allergic Responses, The American Journal of Chinese Medicine, 47, 06, 2019. Crossref
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Huang Yan-Jiun, Yadav Vijesh Kumar, Srivastava Prateeti, Wu Alexander TH, Huynh Thanh-Tuan, Wei Po-Li, Huang Chi-Ying F., Huang Tse-Hung, Antrodia cinnamomea Enhances Chemo-Sensitivity of 5-FU and Suppresses Colon Tumorigenesis and Cancer Stemness via Up-Regulation of Tumor Suppressor miR-142-3p, Biomolecules, 9, 8, 2019. Crossref
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Lin Liang-Hung, Chi Ching-Hsin, Zhang Xiao-Han, Chen Ying-Ju, Wang Ming-Fu, Immunomodulatory Effects of Fruiting Body Extract and Solid-State-Cultivated Mycelia of Taiwanofungus camphoratus, Nutrients, 11, 9, 2019. Crossref
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Lu Kuan-Hung, Pan Yi-Chun, Sheen Lee-Yan, Combination of cut-log cultivated fruiting body and solid-state cultured mycelia of Taiwanofungus camphoratus ameliorates CCl4-induced liver injury in rats, Journal of Traditional and Complementary Medicine, 10, 2, 2020. Crossref
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Huang Tse-Hung, Chiu Yi-Han, Chan Yi-Lin, Wang Hang, Li Tsung-Lin, Liu Chien-Yin, Yang Cheng-Ta, Lee Tzung-Yan, You Jyh-Sheng, Hsu Kuang-Hung, Wu Chang-Jer, Antrodia cinnamomeaalleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice, Oncotarget, 6, 28, 2015. Crossref
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Chen Wan-Jing, Chang Fung-Wei, A Pilot Study to Assess Food Safety and Potential Cholesterol-Lowering Efficacy of Antrodia cinnamomea Solid-State Cultivated Mycelium in Healthy Adults, Evidence-Based Complementary and Alternative Medicine, 2020, 2020. Crossref
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Kushairi Naufal, Tarmizi Nor Athirah Kamaliah Ahmad, Phan Chia Wei, Macreadie Ian, Sabaratnam Vikineswary, Naidu Murali, David Pamela, Modulation of neuroinflammatory pathways by medicinal mushrooms, with particular relevance to Alzheimer's disease, Trends in Food Science & Technology, 104, 2020. Crossref
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Chang Chi-Chang, Lu Yung-Chuan, Wang Chih-Chun, Ko Tsui-Ling, Chen Jung-Ren, Wang Wei, Chen Ya-Ling, Wang Yu-Wen, Chang Tzu-Hsien, Hsu Hsia-Fen, Houng Jer-Yiing, Antrodia cinnamomea Extraction Waste Supplementation Promotes Thermal Stress Tolerance and Tissue Regeneration Ability of Zebrafish, Molecules, 25, 18, 2020. Crossref
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Chung Yuan‑Chiang, Tzeng Chung‑Yuh, Chen Ying‑I, Chang Shu‑Wei, Hsu Tai‑Hao, Ho Wai‑Jane, Kuo Yueh‑Hsiung, Hung Pei‑Hsiu, Chang Shih‑Liang, Improving insulin resistance with Antrodia cinnamomea mycelium powder to induce a hypoglycemic effect in dexamethasone‑induced insulin‑resistant rats, Molecular Medicine Reports, 2017. Crossref
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Yang Hsin-Ling, Kuo Ya-Ting, Vudhya Gowrisankar Yugandhar, Lin Kai-Yuan, Hsu Li-Sung, Huang Pei-Jane, Lin Hui-Chang, Hseu You-Cheng, The Leaf Extracts of Toona sinensis and Fermented Culture Broths of Antrodia camphorata Synergistically Cause Apoptotic Cell Death in Promyelocytic Leukemia Cells, Integrative Cancer Therapies, 19, 2020. Crossref
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Mirzaei Sepideh, Saebfar Hamidreza, Gholami Mohammad Hossein, Hashemi Farid, Zarrabi Ali, Zabolian Amirhossein, Entezari Maliheh, Hushmandi Kiavash, Samarghandian Saeed, Aref Amir Reza, Ashrafizadeh Milad, Khan Haroon, MicroRNAs regulating SOX2 in cancer progression and therapy response, Expert Reviews in Molecular Medicine, 23, 2021. Crossref
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Chen Yun-Yu, Lo Chiu-Ping, Lin Chin-Chung, Hsieh Yi-Hsuan, Effects of Taiwanofungus camphoratus on non-specific and specific immune activities in mice, Mycology, 9, 2, 2018. Crossref
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Perera Namal, Yang Feng-Ling, Chang Ching-Ming, Lu Yueh-Tung, Zhan Shih-Hao, Tsai Yi-Ting, Hsieh Jung-Feng, Li Lan-Hui, Hua Kuo-Feng, Wu Shih-Hsiung, Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages, Organic Letters, 19, 13, 2017. Crossref
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Zhang Yan, Ma Aijin, Xi Hao, Chen Ning, Wang Rong, Yang Chenhui, Chen Jinbang, Lv Pin, Zheng Fuping, Kang Wenyi, Antrodia cinnamomea ameliorates neointimal formation by inhibiting inflammatory cell infiltration through downregulation of adhesion molecule expression in vitro and in vivo, Food Science and Human Wellness, 10, 4, 2021. Crossref
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Hseu You‐Cheng, Chang Geng‐Ruei, Pan Jian‐You, Rajendran Peramaiyan, Mathew Dony Chacko, Li Mei‐Ling, Liao Jiunn‐Wang, Chen William Tzu‐Liang, Yang Hsin‐Ling, Antrodia camphorata inhibits epithelial‐to‐mesenchymal transition by targeting multiple pathways in triple‐negative breast cancers , Journal of Cellular Physiology, 234, 4, 2019. Crossref
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Kao Shung-Te, Kuo Yueh-Hsiung, Wang Shulhn-Der, Hong Hong-Jye, Lin Li-Jen, Analogous corticosteroids, 9A and EK100, derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages, Cytokine, 108, 2018. Crossref