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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Screening Systems for Medicinal Basidiomycetes Antitumor Extracts

巻 7, 発行 3, 2005, pp. 423-425
DOI: 10.1615/IntJMedMushrooms.v7.i3.660
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要約

Prevention and treatment of oncological diseases is one of the most important fields of possible practical application of preparations on the basis of medicinal Basidiomycetes. The present experimental data demonstrate the ability of mushrooms to synthesize metabolites, revealing anticarcinogenic effects, possessing antitumor activities due to cytostatic or/and immunostimulating action, and inhibiting the process of metastasis. One of the most important current problems in our view is the development or screening systems for mushroom antitumor preparations, including their effectiveness and cost. The present investigation is the first step in this direction.
Strains of Ganoderma lucidum (W.Curt.:Fr.) Lloyd, Hericium erinaceus (Bull.:Fr.) Pers., Lentinus edodes (Berk.) Singer, Trametes versicolor (L.:Fr.) Pilát, having taxonomic proximity and affiliation with the group of xylosaprotrophes (causing white mould) due to their ability to use lignin, was studied.
The action of extracts of submerged mycelium, fruit bodies, and basidiospores from Russian and Chinese mushroom farm was investigated.
Submerged cultivation was carried out in the Gause Institute of New Antibiotics of Russian Academy of Medical Sciences. The strategy for developing methods of submerged cultivation of the species studied, which secures maximal shortage of cultivation costs owing to possibilities of strain diversity, reduction of process length 2−4 times, and increase of biomass yield was worked out. The methods of submerged culture were developed individually for each studied object and included the mice, and in 9-month-old adult mice antitumor growth was not effected by itself but authentically strengthened the CF effect. A similar effect was observed in adult (5-month-old) mice after oral introduction of G. lucidum mycelium combined extract. Thus, the dependence of the antitumor effect of the mushroom extract on the age of the laboratory animal age was determined.
Some additives were selected to strengthen the antitumor effect of G. lucidum mycelium extracts. The highest self-activity was shown by orally introduced mycelium polysaccharide fractions with various ratios of monosaccharides.
Unlike basidiom extracts, submerged mycelium extracts of Hericium erinaceus showed self-antitumor activity on a solid lymphoma model, resulting in inhibition of tumor growth. This effect was distinctly increased by the single prior introduction of a low dose (50 mg/kg)of CF.

によって引用された
  1. Vetchinkina Elena, Fomin Alexander, Navolokin Nikita, Shirokov Alexander, Proteins and polysaccharides from vegetative mycelium of medicinal basidiomycete Lentinus edodes display cytotoxicity towards human and animal cancer cell lines, International Journal of Biological Macromolecules, 195, 2022. Crossref

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