ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018025886
pages 213-225

Hepatoprotective Effect of Auricularia delicata (Agaricomycetes) from India in Rats: Biochemical and Histopathological Studies and Antimicrobial Activity

Sujata Devi Wangkheirakpam
Department of Biotechnology, Institute of Bioresources and Sustainable Development, Government of India, Takyelpat, Imphal Manipur, India; Department of Chemistry, National Institute of Technology–Manipur, Langol, Manipur, India
Devi Datt Joshi
Department of Biotechnology, Institute of Bioresources and Sustainable Development, Government of India, Takyelpat, Imphal Manipur, India
Geeta Devi Leishangthem
Animal Disease Research Centre, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
Dipak Biswas
Department of Chemistry, National Institute of Technology–Manipur, Langol, Manipur, India
Lokesh Deb
Department of Chemistry, National Institute of Technology–Manipur, Langol, Manipur, India

要約

Auricularia delicata, an edible mushroom, has been used as a traditional medicine in Manipur, India, for various gastrointestinal and liver ailments. This study evaluates the antioxidant, antimicrobial, and hepatoprotective potential of A. delicata. A. delicata fruiting bodies were extracted with hexane, chloroform, ethyl acetate, and methanol. All these extracts were examined for in vitro antioxidant activity. To study antimicrobial activity, minimum inhibitory concentrations (milligrams per milliliter) were determined through the use of the broth dilution method. In vivo hepatoprotective activity against acetaminophen-induced hepatic injury in rats was investigated by evaluating serum biochemistry, antioxidant enzymes, and histopathology. With regard to antioxidant activity, 21 and 48 μg/mL were the lowest half-maximal effective concentrations, obtained for the methanol and ethyl acetate fractions, respectively. In the antimicrobial study, the ethyl acetate fraction showed the lowest inhibition of Bacillus subtilis, Enterococcus feacium, Streptococcus aureus, B. cereus, and Escherichia coli, with minimum inhibitory concentrations of 0.03, 0.015, 0.03, 0.11, and 0.5 mg/mL, respectively. Further, in in vivo studies, elevated levels of biochemical markers were significantly returned to near normal values; this was supported by histopathological changes. Thus A. delicata showed antimicrobial, antioxidant, and protective roles in induced hepatic injury. Phytochemical analysis using high-performance liquid chromatography revealed the presence of chlorogenic acid in the extracts. Its protective property might be due to the presence of a mitochondrial-targeted antioxidant effect of chlorogenic acid. The antimicrobial activity accounts for its use against diarrhea. Hence, A. delicata could be one of the best sources for natural gastrointestinal and hepatoprotective medicines in the future.


Articles with similar content:

Antitumor and Wound Healing Properties of Rubus niveus Thunb. Root
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Thankarajan Sajeesh, Thangaraj Parimelazhagan, Shanmugam Saravanan, Blassan Plackal George
Antioxidant and Antigenotoxicity Activities of Extracts from Liquid Submerged Culture of Culinary-Medicinal Ferula Oyster Mushroom, Pleurotus eryngii (DC.) Quél. var. ferulae (Lanzi) Sacc. (Agaricomycetideae)
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 4
Shu-Ling Hsieh, Juang-Lin Lien, Jinn-Chyi Wang, Shu-Hui Hu, Sue-Joan Chang
Antioxidant Activity of Different Fractions of Methanolic Extract of the Golden Chanterelle Mushroom Cantharellus cibarius (Higher Basidiomycetes) from Iran
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 6
Masoumeh Khalili, Yaghoub Safdari, Mohammad Ali Ebrahimzadeh
Determination of the Antioxidant Activity and Polyphenol Contents of Wild Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W.Curt. Fr.) P. Karst. (Higher Basidiomycetes) from Central Himalayan Hills of India
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 6
Prem Singh Negi, Zakwan Ahmed, Mohammed Mohsin
Assessment of the Gastroprotective Effect of the Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Against the Gastric Mucosal Ulceration Induced by Ethanol in Experimental Rats
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 8
Jing Qu, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Xin Xin, Kebin Gu