年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Antitumor Activity of Extracts from Medicinal Basidiomycetes Mushrooms
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要約
Aqueous extracts from the vegetative submerged mycelia of cultivated Basidiomycetes Ganoderma lucidum, Lentinus edodes, and Grifola frondosa, as well as from the fruiting bodies of G. lucidum, were found to have antitumor activity. The antitumor effect of the mycelial extracts from all 3 fungal species was ascertained in vivo in rats with implanted kidney cancer. Dystrophic changes in tumor cells and tumor necrosis (up to 90%) were noted. In vitro cytotoxicity studies of the A549 human lung adenocarcinoma cell line and HEp-2 human laryngeal epidermoid carcinoma cells showed that the extracts from the G. lucidum fruiting bodies and from the L. edodes vegetative mycelium were the most effective. The animals' immune systems were activated, and the fungal extracts displayed no toxicity when administered orally.
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Mahfuz Shad, Piao Xiangshu, Use of Medicinal Mushrooms in Layer Ration, Animals, 9, 12, 2019. Crossref
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Vetchinkina Elena, Fomin Alexander, Navolokin Nikita, Shirokov Alexander, Proteins and polysaccharides from vegetative mycelium of medicinal basidiomycete Lentinus edodes display cytotoxicity towards human and animal cancer cell lines, International Journal of Biological Macromolecules, 195, 2022. Crossref
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Khatun Mst Afifa, Sato Shinji, Konishi Tetsuya, Obesity preventive function of novel edible mushroom, Basidiomycetes-X (Echigoshirayukidake): Manipulations of insulin resistance and lipid metabolism, Journal of Traditional and Complementary Medicine, 10, 3, 2020. Crossref
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Yang Rui , Dong Shanjun , Luo Jiahao , Ma Feifei , Jiang Wenming , Han Chun-Chao, Research Progress on the Function and Application of Proteins of Edible and Medicinal Mushrooms: A Review , International Journal of Medicinal Mushrooms, 24, 12, 2022. Crossref