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Critical Reviews™ in Eukaryotic Gene Expression

年間 6 号発行

ISSN 印刷: 1045-4403

ISSN オンライン: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

The Control of Meiotic Recombination in the Human Genome

巻 28, 発行 3, 2018, pp. 187-204
DOI: 10.1615/CritRevEukaryotGeneExpr.2018024601
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要約

Meiotic recombination plays a key role in reshuffling haplotypes in human populations and thus affects evolution profoundly. However, our understanding of recombination dynamics is largely limited to descriptions of variation in populations and families. Higher-resolution analysis (≤ 0.0001 cM) of de novo recombination events in human sperm DNA has revealed clustering into very narrow hotspots (1–2 kb) that generally coincide with abrupt breakdown of linkage disequilibrium. Recent findings have highlighted an unexpected molecular control of the distribution of meiotic double-strand breaks (DSBs) in mammals by a rapidly evolving gene in trans, PR-domain-containing 9 (PRDM9), and specific DNA sequence motifs in cis. In addition, the understanding of new regulators in DSB repair processes has allowed the delineation of recombination pathways that have two major outcomes, cross-overs and non-cross-overs, which have distinct mechanistic roles and consequences for genome evolution. Further molecular studies are needed to gain information about how hotspots originate, function, and evolve.

キーワード: hotspot, meiosis, diversity
によって引用された
  1. Anand Sumit Kr, Sharma Ankita, Singh Neha, Kakkar Poonam, Entrenching role of cell cycle checkpoints and autophagy for maintenance of genomic integrity, DNA Repair, 86, 2020. Crossref

  2. Teves Maria Eugenia, Roldan Eduardo R. S., Sperm bauplan and function and underlying processes of sperm formation and selection, Physiological Reviews, 102, 1, 2022. Crossref

  3. Protacio Reine U., Davidson Mari K., Wahls Wayne P., Adaptive Control of the Meiotic Recombination Landscape by DNA Site-dependent Hotspots With Implications for Evolution, Frontiers in Genetics, 13, 2022. Crossref

  4. Protacio Reine U, Mukiza Tresor O, Davidson Mari K, Wahls Wayne P, Bhalla N, Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination, Genetics, 220, 2, 2022. Crossref

  5. Hirota Kouji, Regulation Mechanisms of Meiotic Recombination Revealed from the Analysis of a Fission Yeast Recombination Hotspot ade6-M26, Biomolecules, 12, 12, 2022. Crossref

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