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Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v22.i2.10
pages 87-95

Ciliary Epithelium: An Underevaluated Target for Therapeutic Regeneration

Chandrika Abburi
Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Neuroscience Research Laboratory, Chandigarh-160012, India
Akshay Anand
Neuroscience Research Lab, Post Graduate Institute of Medical Education and Research, Chandigarh, India

要約

The purpose of stem cells in various organs of vertebrates is to replenish dying cells or to replace damaged tissues. However, a few organs have reasonable, while others have very limited regenerative, capacity. Until the last two decades, the organs such as brain, heart, and kidneys were known to lack regenerative capacity for lack of resident stem cell population. However, with advancement of techniques and an increase in scientific communication, new discoveries have brought novel concepts and data to discover and manipulate these valuable resources. Much focus has been devoted to understanding the regulation and maintenance of these stem cells. We discuss the preclinical data emerging from retino-vascular interactions useful in the exploitation of ciliary epithelium−derived stem cells for therapeutic regeneration.