年間 6 号発行
ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502
Indexed in
Association between Methionine Synthase Reductase A66G Polymorphism and Male Infertility: A Meta-Analysis
要約
The aim of this meta-analysis was to assess the methionine synthase reductase (MTRR) gene 66A>G polymorphism and male infertility susceptibility. Studies were identified in PubMed and Embase databases. An odds ratio (OR) was used to assess the relationship between MTRR 66A>G polymorphism and male infertility risk. A total of seven case-control studies containing 1438 patients and 1363 controls were enrolled in the meta-analysis. Our results showed that no association exists between the MTRR 66A>G polymorphism and male infertility risk in the total population (GG vs. AA: OR = 1.29, 95% confidence interval [CI] = 1.00-1.66; GA vs. AA: OR = 1.09, 95% CI = 0.92-1.30; dominant model: OR = 1.13, 95% CI = 0.96-1.34; recessive model: OR = 0.83, 95% CI = 0.67–1.03). In a subgroup analysis by nationality, the 66A>G polymorphism was not associated with male infertility in both Asians and Caucasians. In a subgroup analysis stratified by male infertility type, significant association was found with oligoasthenozoospermia (OAT) (GG vs. AA: OR = 1.83, 95% CI = 1.24-269; GA vs. AA: OR = 1.36, 95% CI = 0.88-2.11; dominant model: OR = 1.51, 95% CI = 1.13-2.01; recessive model: OR = 0.62, 95% CI = 0.46-0.85). In summary, the present meta-analysis suggests that MTRR 66A>G polymorphism may be associated with OAT risk.
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Shi Tian-Lu, Wu Yan, Li Yu, Chen Zhen-Feng, Ma Yi-Ni, Zhang Zhe-Tao, Zhang Yong-Huang, Zhang Lei, The relevance of MTHFR C677T, A1298C, and MTRR A66G polymorphisms with response to male infertility in Asians, Medicine, 98, 8, 2019. Crossref
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Ren Zheng-Ju, Zhang Yan-Ping, Ren Peng-Wei, Yang Bo, Deng Shi, Peng Zhu-Feng, Liu Liang-Ren, Wei WuRan, Dong Qiang, Contribution of MTR A2756G polymorphism and MTRR A66G polymorphism to the risk of idiopathic male infertility, Medicine, 98, 51, 2019. Crossref
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Review of Cell and Molecular Biology, in In-Vitro Fertilization, 2019. Crossref