ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2014012215
pages 357-378

Current Major Advances in the Regulation of Milk Protein Gene Expression

Xi Qian
Laboratory of Lactation and Metabolic Physiology, Department of Animal Science, University of Vermont, Burlington, VT
Feng-Qi Zhao
Laboratory of Lactation and Metabolic Physiology, Department of Animal Science, University of Vermont, Burlington, VT

要約

During lactation, functionally differentiated mammary epithelial cells convert circulating nutrients into various milk components, providing all essential nutrients for the growth and development of mammal neonates. One of the major milk components is milk protein, which includes the casein and whey proteins. Regulation of milk protein gene expression is dependent on hormonal and developmental cues that modulate the activity of specific transcription factors and change the chromatin structure in mammary epithelial cells. Understanding the underlying mechanisms involved in mammary-specific milk protein gene regulation will help improve the yield, quality, and efficiency of milk production and identify important signaling factors and pathways involved in mammary development, differentiation, lactation, and disease. In this review we first review advances in the understanding of the regulatory mechanisms of milk protein genes by hormones, growth factors, and the extracellular matrix, with a focus on transcriptional regulation. We then discuss the relationship between chromatin structure and milk protein gene expression from an epigenetic perspective. Finally, we summarize recent achievements using the mammary gland as a bioreactor for producing pharmaceutical proteins for human use.


Articles with similar content:

Cell Nucleus in Context
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 1
Sophie Lelievre, Mina J. Bisseil, Philippe Pujuguet
YY1 Is an Inducer of Cancer Metastasis
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Guangchao Sui, Dangdang Li, Wenmeng Wang
Insights on the Functional Role of Chromatin Remodelers in Osteogenic Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 2
Nitsan Shacham, Dafna Benayahu, Irena Shur
Regulatory Controls for Osteoblast Growth and Differentiation: Role of Runx/Cbfa/AML Factors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 1&2
Sayyed Kaleem Zaidi, Janet L. Stein, Jane B. Lian, Martin Montecino, Andre J. van Wijnen, Amjad Javed, Gary S. Stein, Christopher Lengner
Genetic and Epigenetic Control of RKIP Transcription
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 6
Milad S. Bitar, Kevin Qin, Kam C. Yeung, Fahd Al-Mulla, Hanna Tegegne, Ila Datar, Robert J. Trumbly