ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i4.30
pages 323-336

Replication of Damaged Genomes

Alden C. Klarer
Department of Biochemistry and Molecular Biology, University of Louisville; James Graham Brown Cancer Center, University of Louisville
W. Glenn McGregor
University of Louisville

要約

Cellular DNA is continuously assaulted by chemical and physical agents that arise from both endogenous metabolic processes as well as exogenous insults. Commonly encountered environmental agents include polyaromatic hydrocarbons, polycyclic aromatic amines, the ultraviolet component of sunlight, and ionizing radiation, among many others. Although the kinds of damages and the mechanisms involved in their interaction with DNA vary widely, genotoxic agents alter the structure of DNA in ways that may result in permanent alterations in the DNA sequence or in cell death. To avoid these consequences, cells have evolved countermeasures to reduce the biological consequences of DNA damage. These mechanisms are highly conserved and are present in all eukaryotic cells. In general, cellular responses include the detection of damage, signal transduction to halt cell cycle progression, and the recruitment of repair mechanisms that are tailored to the specific kind of damage. If replication-blocking damage remains when cells enter S-phase, then tolerance mechanisms in the form of complex recombination mechanisms or translesion DNA synthesis using accessory DNA polymerases exist. These mechanisms complete the replication of damaged genomes and suppress cytotoxicity, but at the potential cost of mutagenesis and genomic instability. This review focuses on error-prone mechanisms, including a discussion of the Y-family of DNA polymerases, current concepts of DNA polymerase switching mechanisms, and their relevance to cancer and cancer prevention.


Articles with similar content:

Breakpoint Clusters: Reason or Consequence?
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 1&2
Andrey A. Bystritskiy, Sergey V. Razin
Centrosomes, Genomic Instability, and Cervical Carcinogenesis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.13, 2003, issue 1
Stefan Duensing, Karl Munger
Genome Instability in the Context of Chromatin Structure and Fragile Sites
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 3
Eva Bartova, Gabriela Galiova, Sona Legartova, Alzbeta Jugova, Lenka Stixova, Stanislav Kozubek
Cell Cycle and Cancer: Critical Events at the G1 Restriction Point
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 1-2
Michele Pagano, Massimo Loda, Giannino DelSal
Exosomes, Ectosomes and the Two Together. Physiology and Pathology
Forum on Immunopathological Diseases and Therapeutics, Vol.6, 2015, issue 3-4
Jacopo Meldolesi