ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 2.156 5年インパクトファクター: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i4.10
pages 303-311

Review on Regulation of Inwardly Rectifying Potassium Channels

Junshuai Wang
Tongji Hospital of Wuhan
Yuancheng Huang
Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Qin Ning
Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology

要約

An inwardly rectifying potassium channel (Kir) is a kind of protein complex that is widely expressed on excitable and nonexcitable cell membranes. Kir channels serve important roles in cellular physiology such as cell excitability and K+ homeostasis. The Kirs (KIR1-7) are regulated by many factors: phosphatidylinosital-4, 5-bisphosphate (PIP2), ATP, or G-proteins. Other factors like polyamines, kinases, pH, and Na+ ions act cooperatively to modulate Kir channels. Different types and specific distributions of KIR channels determine the diversity of regulatory mechanisms. This review provides insight into Kir channel regulation.


Articles with similar content:

Developmental Aspects of NMDA Receptor Function
Critical Reviews™ in Neurobiology, Vol.12, 1998, issue 3
Mary Lou Vallano
Adenosine and Adenine Nucleotides as Regulators of Cerebral Blood Flow: Roles of Acidosis, Cell Swelling, and KATP Channels
Critical Reviews™ in Neurobiology, Vol.16, 2004, issue 4
John W. Phillis
Inositol 1,4,5-Trisphosphate Receptors and Calcium Signaling
Critical Reviews™ in Neurobiology, Vol.10, 1996, issue 1
Takayuki Michikawa, Katsuhiko Mikoshiba, Teiichi Furuichi, Atsushi Miyawaki
Signaling Pathways Involved in Glucocorticoid-Induced Apoptosis of Thymocytes
Critical Reviews™ in Immunology, Vol.25, 2005, issue 4
Francoise Giraud, Jean-Claude Sulpice, Sandrine Lepine
Oncogenes and Signal Transduction Pathways Involved in the Regulation of Na+ Channel Expression
Critical Reviews™ in Oncogenesis, Vol.9, 1998, issue 1
Sadatoshi Tsuji, Shunsuke Sashihara, Takashi Matsui