年間 6 号発行
ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502
Indexed in
Circulating versus Local Angiotensin II in Blood Pressure Control: Lessons from Tissue-Specific Expression of Angiotensin-Converting Enzyme (ACE)
要約
The renin angiotensin system (RAS) is a central player in blood pressure control. Its effector peptide, angiotensin II, regulates blood pressure through coordinated actions in multiple tissues. The RAS is generally considered to be an endocrine system, and angiotensin II to be a circulating hormone. In recent years, however, a role for locally produced angiotensin II has been proposed. The major site for angiotensin II production is endothelium, where angiotensin-converting enzyme (ACE) is abundantly expressed. To elucidate the relative importance of circulating angiotensin II versus locally produced angiotensin II, one approach is to create a mouse model in which ACE is expressed in a tissue-specific manner. In this review, we discuss strategies to create such a model. In a mouse model we generated using a novel promoter-swapping technique, the endothelial ACE is eliminated and replaced by ectopic production of ACE in the liver. This model specifically addresses the question of whether local production of angiotensin II is essential for RAS function.
-
Kisseleva Tatiana, Brenner David A, Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis, Journal of Gastroenterology and Hepatology, 22, s1, 2007. Crossref
-
Muñoz Marina C, Argentino Danila P, Dominici Fernando P, Turyn Daniel, Toblli Jorge E, Irbesartan restores the in-vivo insulin signaling pathway leading to Akt activation in obese Zucker rats, Journal of Hypertension, 24, 8, 2006. Crossref
-
Uranga Romina M., Bruce-Keller Annadora J., Morrison Christopher D., Fernandez-Kim Sun Ok, Ebenezer Philip J., Zhang Le, Dasuri Kalavathi, Keller Jeffrey N., Intersection between metabolic dysfunction, high fat diet consumption, and brain aging, Journal of Neurochemistry, 114, 2, 2010. Crossref
-
Janciauskiene S.M., Erikson C., Warkentin S., A link between sICAM-1, ACE and parietal blood flow in the aging brain, Neurobiology of Aging, 30, 9, 2009. Crossref
-
Huentelman Matthew J., Zubcevic Jasenka, Katovich Michael J., Raizada Mohan K., Cloning and characterization of a secreted form of angiotensin-converting enzyme 2, Regulatory Peptides, 122, 2, 2004. Crossref
-
Probstfield Jeffrey L., O'Brien Kevin D., Progression of Cardiovascular Damage: The Role of Renin–Angiotensin System Blockade, The American Journal of Cardiology, 105, 1, 2010. Crossref
-
Kim Yong-Hoon, Hwang Jung Hwan, Kim Kyung-Shim, Noh Jung-Ran, Gang Gil-Tae, Kim Sang-Woo, Jang Seung Pil, Lee Sang-Ju, Her Sung-Ho, Jeong Kyeong-Hoon, Kwak Tae Hwan, Park Woo Jin, Balyasnikova Irina V., Shong Minho, Lee Chul-Ho, NQO1 activation regulates angiotensin-converting enzyme shedding in spontaneously hypertensive rats, Cardiovascular Research, 99, 4, 2013. Crossref
-
Ronchi Fernanda A, Irigoyen Maria-Claudia, Casarini Dulce E, Association of somatic and N-domain angiotensin-converting enzymes from Wistar rat tissue with renal dysfunction in diabetes mellitus, Journal of the Renin-Angiotensin-Aldosterone System, 8, 1, 2007. Crossref
-
Kennedy Simon, Touyz Rhian M., Anatomy and Pharmacology of Vessels, in Textbook of Vascular Medicine, 2019. Crossref
-
Kohlstedt Karin, Kellner Roland, Busse Rudi, Fleming Ingrid, Signaling via the Angiotensin-Converting Enzyme Results in the Phosphorylation of the Nonmuscle Myosin Heavy Chain IIA, Molecular Pharmacology, 69, 1, 2006. Crossref
-
Scholten D., Brenner D., Current concept of hepatic fibrogenesis in mouse models of liver fibrosis, in Liver Cirrhosis: From Pathophysiology to Disease Management, 162, 2008. Crossref
-
Brito Pamela L., dos Santos Alisson F., Chweih Hanan, Favero Maria E., Gotardo Erica M. F., Silva Juliete A. F., Leonardo Flavia C., Franco-Penteado Carla F., de Oliveira Mariana G., Ferreira Wilson A., Zaidan Bruna C., Billis Athanase, Baldanzi Giorgio, Mashima Denise A., Antunes Edson, Saad Sara T. Olalla, Costa Fernando F., Conran Nicola, Connes Philippe, Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition, PLOS ONE, 17, 2, 2022. Crossref
-
Fleming Ingrid, Signaling by the Angiotensin-Converting Enzyme, Circulation Research, 98, 7, 2006. Crossref
-
Rommel Carolin, Rösner Stephan, Lother Achim, Barg Margareta, Schwaderer Martin, Gilsbach Ralf, Bömicke Timo, Schnick Tilman, Mayer Sandra, Doll Sophia, Hesse Michael, Kretz Oliver, Stiller Brigitte, Neumann Franz-Josef, Mann Matthias, Krane Markus, Fleischmann Bernd K., Ravens Ursula, Hein Lutz, The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia, Circulation Research, 123, 5, 2018. Crossref
-
Rice Gillian I., Jones Amy L., Grant Peter J., Carter Angela M., Turner Anthony J., Hooper Nigel M., Circulating Activities of Angiotensin-Converting Enzyme, Its Homolog, Angiotensin-Converting Enzyme 2, and Neprilysin in a Family Study, Hypertension, 48, 5, 2006. Crossref