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Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v19.i4.20
pages 267-287

The Role of the Leptin-Melanocortin Signalling Pathway in the Control of Food Intake

Sigri Beckers
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Doreen Zegers
Department of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium
Luc F. Van Gaal
Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Antwerp
Wim Van Hul
Department of Medical Genetics, University of Antwerp (UA) and Department of Medical Genetics, University Hospital of Antwerp (UZA)

要約

Obesity is one of the most important health problems today. Obesity is mostly caused by a complex interaction between environmental and genetic factors. However, several monogenic forms of obesity also exist. Te mutations causing these forms of obesity were all found in genes involved in the leptin-melanocortin pathway: leptin, leptin receptor, proopiomelanocortin, prohormone convertase 1, and melanocortin-4 receptor. Recently, several novel players with a role in this pathway have been identified and have increased our knowledge on the regulation of food intake. These include the melanocortin-3 receptor, BDNF, SIM1, and nesfatin-1. In this review, we will discuss the most important players involved in this pathway. We will focus on genetic studies concerning mouse models involving these genes and reported human variation in these genes. We intend to provide an extensive overview of all currently known proteins with a significant role in this pathway. Together, these data demonstrate the importance of this pathway in the regulation of food intake and the pathogenesis of obesity.


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