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Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v8.i2.30
pages 141-168

Nuclear Hormone Receptors and Adipogenesis

Jeffrey M. Gimble
Stem Cell Biology Laboratory, 3Clinical Nutrition Research Unit, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Claudius E. Robinson
Departments of Zoology, University of Oklahoma, Norman, OK, 73019
Stephen L . Clarke
Departments of Nutrition The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Oklahoma State University, Department of Nutritional Sciences, Stillwater, OK 74078, USA
Molly R. Hill
Departments of Radiologic Technology The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104

要約

Adipocytes provide a model cell system for exploring the complexities of nuclear hormone receptor transcriptional regulation. Adipocytes produce lipid and cholesterol metabolites which can serve as activating ligands for many of the classic and "orphan" nuclear hormone receptors. At the same time, nuclear hormone receptors directly control adipocyte commitment. The recently described nuclear hormone receptor coactivators and corepressors provide an additional level of complexity to this system. This review emphasizes available in vitro and in vivo models and discusses them in the context of current controversies and future experimental directions.


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