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Critical Reviews™ in Eukaryotic Gene Expression

年間 6 号発行

ISSN 印刷: 1045-4403

ISSN オンライン: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Contributions of the Histone Arginine Methyltransferase PRMT6 to the Epigenetic Function of RUNX1

巻 23, 発行 3, 2013, pp. 265-274
DOI: 10.1615/CritRevEukaryotGeneExpr.2013007527
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要約

Hematopoietic differentiation is directed by transcription factors such as RUNX1. RUNX1 binds to specific DNA binding sites in regulatory elements of genes and recruits epigenetic cofactors to target loci. In this way histone modification patterns and the chromatin environment are altered, which results in adjusted gene expression. The process of transcription factor binding and cofactor recruitment is dynamic and strongly influenced by specific posttranslational modifications, which are triggered by signaling. In this way cellular signaling is integrated at the epigenetic level by transcription factors. The identification of epigenetic cofactors and the study of their epigenetic influence on transcription is crucial for the understanding of transcription factor function in differentiation and disease. In this article, the recent observation that RUNX1 is associated with the protein arginine methyltransferase 6 will be reviewed. PRMT6 triggers H3R2me2a at RUNX1 target genes; this histone modification negatively influences the positive H3K4me3 mark and this way acts repressive. The RUNX1/PRMT6 association has an impact on bivalent histone marks. Upon differentiation, a RUNX1 corepressor complex with PRMT6 is exchanged with a RUNX1 coactivator complex. Furthermore, the potential cross talk of transcription factors and epigenetic cofactors with histone marks will be discussed.

によって引用された
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  6. Teng Xu, Wang Pei, Yang Tianshu, Huang Wei, Yu Hefeng, Li Weishi, Chen Zhongqiang, Fan Dongwei, Inhibition of osteoblast proliferation and migration by exogenous and endogenous formaldehyde, Human & Experimental Toxicology, 40, 5, 2021. Crossref

  7. Gupta Somlee, Kadumuri Rajashekar Varma, Singh Anjali Kumari, Chavali Sreenivas, Dhayalan Arunkumar, Structure, Activity and Function of the Protein Arginine Methyltransferase 6, Life, 11, 9, 2021. Crossref

  8. Schneider Lucas, Herkt Stefanie, Wang Lei, Feld Christine, Wesely Josephine, Kuvardina Olga N., Meyer Annekarin, Oellerich Thomas, Häupl Björn, Seifried Erhard, Bonig Halvard, Lausen Joern, PRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1, Oncogenesis, 10, 5, 2021. Crossref

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