年間 6 号発行
ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502
Indexed in
Contributions of the Histone Arginine Methyltransferase PRMT6 to the Epigenetic Function of RUNX1
要約
Hematopoietic differentiation is directed by transcription factors such as RUNX1. RUNX1 binds to specific DNA binding sites in regulatory elements of genes and recruits epigenetic cofactors to target loci. In this way histone modification patterns and the chromatin environment are altered, which results in adjusted gene expression. The process of transcription factor binding and cofactor recruitment is dynamic and strongly influenced by specific posttranslational modifications, which are triggered by signaling. In this way cellular signaling is integrated at the epigenetic level by transcription factors. The identification of epigenetic cofactors and the study of their epigenetic influence on transcription is crucial for the understanding of transcription factor function in differentiation and disease. In this article, the recent observation that RUNX1 is associated with the protein arginine methyltransferase 6 will be reviewed. PRMT6 triggers H3R2me2a at RUNX1 target genes; this histone modification negatively influences the positive H3K4me3 mark and this way acts repressive. The RUNX1/PRMT6 association has an impact on bivalent histone marks. Upon differentiation, a RUNX1 corepressor complex with PRMT6 is exchanged with a RUNX1 coactivator complex. Furthermore, the potential cross talk of transcription factors and epigenetic cofactors with histone marks will be discussed.
-
Kuvardina Olga N., Herglotz Julia, Kolodziej Stephan, Kohrs Nicole, Herkt Stefanie, Wojcik Bartosch, Oellerich Thomas, Corso Jasmin, Behrens Kira, Kumar Ashok, Hussong Helge, Urlaub Henning, Koch Joachim, Serve Hubert, Bonig Halvard, Stocking Carol, Rieger Michael A., Lausen Jörn, RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation, Blood, 125, 23, 2015. Crossref
-
Pruitt K., Molecular and Cellular Changes During Cancer Progression Resulting From Genetic and Epigenetic Alterations, in Molecular and Cellular Changes in the Cancer Cell, 144, 2016. Crossref
-
Kohrs Nicole, Kolodziej Stephan, Kuvardina Olga N., Herglotz Julia, Yillah Jasmin, Herkt Stefanie, Piechatzek Alexander, Salinas Riester Gabriela, Lingner Thomas, Wichmann Christian, Bonig Halvard, Seifried Erhard, Platzbecker Uwe, Medyouf Hind, Grez Manuel, Lausen Jörn, Gartenhaus Ronald B, MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO, PLOS Genetics, 12, 3, 2016. Crossref
-
de Bruijn Marella, Dzierzak Elaine, Runx transcription factors in the development and function of the definitive hematopoietic system, Blood, 129, 15, 2017. Crossref
-
Behera Amit K., Kundu Tapas K., Asymmetric Dimethylation on Arginine (ADMA) of Histones in Development, Differentiation and Disease, in The DNA, RNA, and Histone Methylomes, 2019. Crossref
-
Teng Xu, Wang Pei, Yang Tianshu, Huang Wei, Yu Hefeng, Li Weishi, Chen Zhongqiang, Fan Dongwei, Inhibition of osteoblast proliferation and migration by exogenous and endogenous formaldehyde, Human & Experimental Toxicology, 40, 5, 2021. Crossref
-
Gupta Somlee, Kadumuri Rajashekar Varma, Singh Anjali Kumari, Chavali Sreenivas, Dhayalan Arunkumar, Structure, Activity and Function of the Protein Arginine Methyltransferase 6, Life, 11, 9, 2021. Crossref
-
Schneider Lucas, Herkt Stefanie, Wang Lei, Feld Christine, Wesely Josephine, Kuvardina Olga N., Meyer Annekarin, Oellerich Thomas, Häupl Björn, Seifried Erhard, Bonig Halvard, Lausen Joern, PRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1, Oncogenesis, 10, 5, 2021. Crossref
-
Yang Jichun, Ma Jing, Xiong Yu, Wang Yanlin, Jin Kaiyue, Xia Wenjun, Chen Qing, Huang Jianbo, Zhang Jin, Jiang Nan, Jiang Shayi, Ma Duan, Epigenetic regulation of megakaryocytic and erythroid differentiation by PHF2 histone demethylase, Journal of Cellular Physiology, 233, 9, 2018. Crossref
-
Chen Zhixian, Gan Jianfeng, Wei Zhi, Zhang Mo, Du Yan, Xu Congjian, Zhao Hongbo, The Emerging Role of PRMT6 in Cancer, Frontiers in Oncology, 12, 2022. Crossref