ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v18.i1.40
pages 47-56

Gene Expression in Pulmonary Fibrosis

Eileen Hsu
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Hidekata Yasuoka
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Carol A. Feghali-Bostwick
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA

要約

Pulmonary fibrosis is a phenotype that results from a variety of conditions and is associated with significant morbidity and mortality. Ongoing research in the field is driven by the need for effective treatments for pulmonary fibrosis. In this review, we highlight mechanisms that regulate gene expression in pulmonary fibrosis at multiple levels. Potential pathogenic mechanisms involve genetic background and transcriptional, posttranscriptional, translational, posttranslational, and epigenetic mechanisms. Pulmonary fibrosis results from abnormal gene expression and regulation that arise from a combination of inherited/acquired genetic alterations and environmental triggers. Collectively, these alterations result in increased expression of extracellular matrix components such as collagen and fibronectin and in the observed fibrosis. Insights gained from mechanisms identified to induce and/or perpetuate fibrosis in the lung will yield new targets for the development of more effective therapies.


Articles with similar content:

Mechanisms That Contribute to the Development of Lymphoid Malignancies: Roles for Genetic Alterations and Cytokine Production
Critical Reviews™ in Immunology, Vol.16, 1996, issue 1
Kenneth L. Bost, Laura S. Levy
On the Origin of Cancer Metastasis
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 1 - 2
Thomas N. Seyfried, Leanne C. Huysentruyt
Stem Cell-Based Models and Therapies for Neurodegenerative Diseases
Critical Reviews™ in Biomedical Engineering, Vol.37, 2009, issue 4-5
Khaled Alsayegh, Sheena Abraham, Raj R. Rao, Shilpa Iyer
Long-Term Effects of Chromatin Remodeling and DNA Damage in Stem Cells Induced by Environmental and Dietary Agents
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 4
C. Greer Vestal, Christine Richardson, Bhawana Bariar
Identification of the Molecular Basis of Non-thermal Plasma-Induced Changes in Human Keratinocytes
Plasma Medicine, Vol.3, 2013, issue 1-2
Kai Masur, Klaus-Dieter Weltmann, Thomas von Woedtke, Anke Schmidt