年間 6 号発行
ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502
Indexed in
Mechanisms of Tumor Metastasis to Bone
要約
Bone metastases occur in approximately 80% of patients with advanced cancer. They are characterized by cancer cell growth and bone destruction that cause pain, fractures, anemia, and hypercalcemia. At diagnosis, bone metastases are usually incurable owing to their advanced development. However, the early stages in their formation are asymptomatic and begin as single micrometastatic cells from the blood stream. These cells can be detected by molecular analysis of bone marrow in approximately 30% of patients at the time of cancer diagnosis, but not all single micrometastatic cells develop into clinically significant bone metastases. A synergistic relationship exists between the micometastasis and the bone environment creating favorable conditions for the development and growth of disseminated tumor cells. Such bone metastases induce osteolysis or new bone formation, releasing growth factors and cytokines, which in turn amplify this pathological mechanism. The underling hypothesis, first proposed by Paget in 1889, is that the growth of disseminated tumor cells in bone is dependent on the fertility of the soil or bone itself. This article explores the most current opinions in this area of study and presents a comprehensive summary of the major factors involved.
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Marchiori Dennis M., Bone Tumors and Related Diseases, in Clinical Imaging, 2014. Crossref
-
Peter Breslin S.J., Volk Andrew, Zhang Jiwang, The Stem Cell Niche and Its Role in Self-Renewal, Aging, and Malignancy, in Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2013. Crossref
-
Goldstein Robert H, Weinberg Robert A, Rosenblatt Michael, Of mice and (wo)men: Mouse models of breast cancer metastasis to bone, Journal of Bone and Mineral Research, 25, 3, 2010. Crossref
-
Reddi A Hari, Roodman David, Freeman Colette, Mohla Suresh, Mechanisms of Tumor Metastasis to the Bone: Challenges and Opportunities, Journal of Bone and Mineral Research, 18, 2, 2003. Crossref
-
Nguyen Ba D., Urothelial Nodal Metastasis With Direct Vertebral Invasion: PET/CT Imaging, Clinical Nuclear Medicine, 31, 10, 2006. Crossref
-
Bonucci Ermanno, Physiopathology of cancer metastases in bone and of the changes they induce in bone remodeling, Rendiconti Lincei, 13, 3, 2002. Crossref
-
Wittrant Y., Théoleyre S., Chipoy C., Padrines M., Blanchard F., Heymann D., Rédini F., RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1704, 2, 2004. Crossref
-
Nakashima Yasuaki, Metastases Involving Bone, in Bone and Soft Tissue Pathology, 2010. Crossref
-
Li Yue-Nan, Huang Feng-Ying, Mei Wen-Li, Dai Hao-Fu, Guo Jun-Li, Tan Guang-Hong, Zhou Peng, Toxicarioside A, isolated from tropical Antiaris toxicaria, blocks endoglin/TGF-β signaling in a bone marrow stromal cell line, Asian Pacific Journal of Tropical Medicine, 5, 2, 2012. Crossref
-
Larmonier Nicolas, Ghiringhelli Fran�ois, Larmonier Claire B., Moutet Monique, Fromentin Annie, Baulot Emmanuel, Solary Eric, Bonnotte Bernard, Martin Fran�ois, Freshly isolated bone marrow cells induce death of various carcinoma cell lines, International Journal of Cancer, 107, 5, 2003. Crossref
-
Eckhardt B.L., Pouliot N., Anderson R.L., Influence of the Bone Microenvironment on Breast Cancer Metastasis to Bone, in Integration/Interaction of Oncologic Growth, 15, 2005. Crossref
-
Kim Bora, Cho Yong Jin, Park Mineon, Lim Wonbong, Immunization With RANKL Inhibits Osteolytic Bone Metastasis in Breast Cancer, Journal of Immunotherapy, 45, 1, 2022. Crossref
-
Deng Xiyun, Tannehill-Gregg Sarah H., Nadella Murali V. P., He Guangchun, Levine Andrea, Cao Ya, Rosol Thomas J., Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases, Clinical & Experimental Metastasis, 24, 2, 2007. Crossref
-
O'Connor John C., Farach-Carson Mary C., Schneider Charles J., Carson Daniel D., Coculture with Prostate Cancer Cells Alters Endoglin Expression and Attenuates Transforming Growth Factor-β Signaling in Reactive Bone Marrow Stromal Cells, Molecular Cancer Research, 5, 6, 2007. Crossref
-
van Golen Cynthia M., Schwab Tracy S., Kim Bhumsoo, Soules Mary E., Su Oh Sang, Fung Kevin, van Golen Kenneth L., Feldman Eva L., Insulin-Like Growth Factor-I Receptor Expression Regulates Neuroblastoma Metastasis to Bone, Cancer Research, 66, 13, 2006. Crossref
-
Layer G., Skelettmetastasen, in Handbuch diagnostische Radiologie, 2005. Crossref