年間 6 号発行
ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502
Indexed in
Nuclear Trafficking of the G-Protein−Coupled Parathyroid Hormone Receptor
要約
G-protein−coupled receptors are a family of receptors that signal primarily through heterotrimeric G proteins. However, new evidence has emerged to show that the signaling capabilities of the receptors are beyond those of traditional signaling cascades. One such example is that the parathyroid hormone (PTH) type 1 receptor is found not only at the plasma membrane but also in the nucleus of cells in cell lines and tissues. This review discusses the emerging concepts of nuclear PTH signaling and relates this information to the growing field of nuclear G-protein−coupled receptors. We review recently published studies on the mechanism of PTH nuclear localization, its role in the cell nucleus, and the contrasting roles ligands play in regulating the receptors' nuclear localization. The review also discusses the importance of nuclear G-protein−coupled receptors and future directions for research in this field.
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Merlen Clémence, Farhat Nada, Luo Xiaoyan, Chatenet David, Tadevosyan Artavazd, Villeneuve Louis R., Gillis Marc-Antoine, Nattel Stanley, Thorin Eric, Fournier Alain, Allen Bruce G., Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca2+ in adult cardiac myocytes, Journal of Molecular and Cellular Cardiology, 62, 2013. Crossref
-
Brown Dennis, Breton Sylvie, Ausiello Dennis A., Marshansky Vladimir, Sensing, Signaling and Sorting Events in Kidney Epithelial Cell Physiology, Traffic, 10, 3, 2009. Crossref
-
Re Richard N., Cook Julia L., Noncanonical intracrine action, Journal of the American Society of Hypertension, 5, 6, 2011. Crossref
-
Wysolmerski John J., Parathyroid Hormone-Related Protein, in Endocrinology: Adult and Pediatric, 2016. Crossref
-
Monego Giovanni, Lauriola Libero, Ramella Sara, D'Angelillo Rolando Maria, Lanza Paola, Granone Pierluigi, Ranelletti Franco Oreste, Parathyroid Hormone-Related Peptide and Parathyroid Hormone-Related Peptide Receptor Type 1 Expression in Human Lung Adenocarcinoma, Chest, 137, 4, 2010. Crossref
-
Morinelli Thomas A., Luttrell Louis M., Strungs Erik G., Ullian Michael E., Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis, The International Journal of Biochemistry & Cell Biology, 77, 2016. Crossref
-
Ranelletti Franco Oreste, Monego Giovanni, Parathyroid Hormone–Related Peptide Signaling in Cancer, in Cell Signaling & Molecular Targets in Cancer, 2012. Crossref
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Almadori Giovanni, Coli Antonella, De Corso Eugenio, Mele Dario Antonio, Settimi Stefano, Di Cintio Giovanni, Brigato Francesca, Scannone Domenico, Lauriola Libero, Ranelletti Franco Oreste, Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival, BMC Cancer, 22, 1, 2022. Crossref