年間 6 号発行
ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502
Indexed in
Isoform Diversity, Regulation, and Functional Adaptation of Troponin and Calponin
要約
Actin-activated myosin II motor function powers muscle contraction and nonmuscle cell motility. The actin-myosin-derived contractility has evolved with a great diversity in different muscle and cell types. Actin filament-based regulation controls striated muscle contraction and plays a role in modulating smooth muscle contractility and nonmuscle cell motility. This review focuses on the isoform diversity and functional adaptations of troponin in striated muscle and calponin in smooth muscle and nonmuscle cells. The gene regulation, alternative RNA splicing, and posttranslational modifications of troponin I and troponin T are summarized, together with recent progress in calponin studies. The biologic significance of the structural and functional diversity and regulation of troponin and calponin is discussed for roles in normal contractility and diseases.
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Kajioka Shunichi, Takahashi-Yanaga Fumi, Shahab Nouval, Onimaru Mitsuho, Matsuda Miho, Takahashi Ryosuke, Asano Haruhiko, Morita Hiromitsu, Morimoto Sachio, Yonemitsu Yoshikazu, Hayashi Maya, Seki Narihito, Sasaguri Toshiuyki, Hirata Masato, Nakayama Shinsuke, Naito Seiji, Endogenous Cardiac Troponin T Modulates Ca2+-Mediated Smooth Muscle Contraction, Scientific Reports, 2, 1, 2012. Crossref
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Lin Jim Jung‐Ching, Li Yan, Eppinga Robbin D., Wang Qinchuan, Jin Jian‐Ping, , 274, 2009. Crossref
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Kern Stephanie, Feng Han-Zhong, Wei Hongguang, Cala Steven, Jin J.-P., Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I, FEBS Open Bio, 4, 1, 2014. Crossref
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Zhang Tan, Birbrair Alexander, Wang Zhong-Min, Taylor Jackson, Messi María Laura, Delbono Osvaldo, Troponin T nuclear localization and its role in aging skeletal muscle, AGE, 35, 2, 2013. Crossref
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Akhter Shirin, Bueltmann Kenneth, Huang Xupei, Jin J.-P., Restrictive cardiomyopathy mutations demonstrate functions of the C-terminal end-segment of troponin I, Archives of Biochemistry and Biophysics, 552-553, 2014. Crossref
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Kracklauer Martin P., Feng Han-Zhong, Jiang Wenrui, Lin Jenny L.-C., Lin Jim J.-C., Jin Jian-Ping, Discontinuous thoracic venous cardiomyocytes and heart exhibit synchronized developmental switch of troponin isoforms, FEBS Journal, 2012. Crossref
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Feng Han-Zhong, Biesiadecki Brandon J., Yu Zhi-Bin, Hossain M. Moazzem, Jin J.-P., Restricted N-terminal truncation of cardiac troponin T: a novel mechanism for functional adaptation to energetic crisis, The Journal of Physiology, 586, 14, 2008. Crossref
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Wu Kai-Chun, Jin J.-P., Calponin in Non-Muscle Cells, Cell Biochemistry and Biophysics, 52, 3, 2008. Crossref
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Debald Manuel, Jin Jian-Ping, Linke Andrea, Walgenbach Klaus-Jürgen, Rauch Peter, Zellmer Angela, Fimmers Rolf, Kuhn Walther, Hartmann Gunther, Walgenbach-Brünagel Gisela, Calponin-h2: a potential serum marker for the early detection of human breast cancer?, Tumor Biology, 35, 11, 2014. Crossref
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Moran Carlos M., Garriock Robert J., Miller Melanie K., Heimark Ronald L., Gregorio Carol C., Krieg Paul A., Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle, Cell Motility and the Cytoskeleton, 65, 8, 2008. Crossref
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Wei Bin, Lu Yingru, Jin J.-P., Deficiency of slow skeletal muscle troponin T causes atrophy of type I slow fibres and decreases tolerance to fatigue, The Journal of Physiology, 592, 6, 2014. Crossref
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Zhang Zhiling, Feng Han-Zhong, Jin J.-P., Structure of the NH2-terminal variable region of cardiac troponin T determines its sensitivity to restrictive cleavage in pathophysiological adaptation, Archives of Biochemistry and Biophysics, 515, 1-2, 2011. Crossref
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Al-Shboul Othman Abdullah, Mustafa Ayman, Mohammad Mukhallad, Al-Shehabat Mustafa, Yousef Asmaa, Al-hashimi Farah, Effect of Oxidative Stress on the Expression of Thin Filament-Associated Proteins in Gastric Smooth Muscle Cells, Cell Biochemistry and Biophysics, 70, 1, 2014. Crossref
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Sheng Juan-Juan, Jin Jian-Ping, Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused review, Frontiers in Physiology, 5, 2014. Crossref
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Appel Sarah, Morgan Kathleen G., Scaffolding proteins and non-proliferative functions of ERK1/2, Communicative & Integrative Biology, 3, 4, 2010. Crossref
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Peng Ying, Ayaz-Guner Serife, Yu Deyang, Ge Ying, Top-down mass spectrometry of cardiac myofilament proteins in health and disease, PROTEOMICS - Clinical Applications, 8, 7-8, 2014. Crossref
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Wei Bin, Jin J.-P., Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function, Archives of Biochemistry and Biophysics, 505, 2, 2011. Crossref
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Moazzem Hossain M., Wang Xin, Bergan Raymond C., Jin J.-P., Diminished expression of h2-calponin in prostate cancer cells promotes cell proliferation, migration and the dependence of cell adhesion on substrate stiffness, FEBS Open Bio, 4, 1, 2014. Crossref
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Jin Jian-Ping, , 321, 2016. Crossref
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Feng Han-Zhong, Hossain M. Moazzem, Huang Xu-Pei, Jin J.-P., Myofilament incorporation determines the stoichiometry of troponin I in transgenic expression and the rescue of a null mutation, Archives of Biochemistry and Biophysics, 487, 1, 2009. Crossref
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Sheng Juan-Juan, Jin Jian-Ping, TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure–function relationships, Gene, 576, 1, 2016. Crossref
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Zhang Zhiling, Akhter Shirin, Mottl Steven, Jin Jian-Ping, Calcium-regulated conformational change in the C-terminal end segment of troponin I and its binding to tropomyosin, FEBS Journal, 278, 18, 2011. Crossref
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Sheng Juan-Juan, Feng Han-Zhong, Pinto Jose R., Wei Hongguang, Jin J.-P., Increases of desmin and α-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction, Journal of Molecular and Cellular Cardiology, 99, 2016. Crossref
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Jin J.-P., Chong Stephen M., Localization of the two tropomyosin-binding sites of troponin T, Archives of Biochemistry and Biophysics, 500, 2, 2010. Crossref
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Chao Erica, Kim Hyun-Woo, Mykles Donald L., Cloning and tissue expression of eleven troponin-C isoforms in the American lobster, Homarus americanus, Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 157, 1, 2010. Crossref
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Chen Yi-Chen, Sumandea Marius P., Larsson Lars, Moss Richard L., Ge Ying, Dissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry, Journal of Muscle Research and Cell Motility, 36, 2, 2015. Crossref
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Mondal Anupom, Jin J.-P., Protein Structure-Function Relationship at Work: Learning from Myopathy Mutations of the Slow Skeletal Muscle Isoform of Troponin T, Frontiers in Physiology, 7, 2016. Crossref
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Moore Jeffrey R., Campbell Stuart G., Lehman William, Structural determinants of muscle thin filament cooperativity, Archives of Biochemistry and Biophysics, 594, 2016. Crossref
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Barnes Dawn E., Hwang Hyundoo, Ono Kanako, Lu Hang, Ono Shoichiro, Molecular evolution of troponin I and a role of its N-terminal extension in nematode locomotion, Cytoskeleton, 73, 3, 2016. Crossref
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Wei Bin, Jin J.-P., TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure–function relationships, Gene, 582, 1, 2016. Crossref
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Genge Christine E., Lin Eric, Lee Ling, Sheng XiaoYe, Rayani Kaveh, Gunawan Marvin, Stevens Charles M., Li Alison Yueh, Talab Sanam Shafaat, Claydon Thomas W., Hove-Madsen Leif, Tibbits Glen F., The Zebrafish Heart as a Model of Mammalian Cardiac Function, in Reviews of Physiology, Biochemistry and Pharmacology, Vol. 171, 171, 2016. Crossref
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Liu Rong, Jin J.-P., Deletion of calponin 2 in macrophages alters cytoskeleton-based functions and attenuates the development of atherosclerosis, Journal of Molecular and Cellular Cardiology, 99, 2016. Crossref
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Zhang Tan, Pereyra Andrea S., Wang Zhong‐Min, Birbrair Alexander, Reisz Julie A., Files Daniel Clark, Purcell Lina, Feng Xin, Messi Maria L., Feng Hanzhong, Chalovich Joseph, Jin Jian‐Ping, Furdui Cristina, Delbono Osvaldo, Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1 , and enhances skeletal muscle force in aging sedentary mice , Aging Cell, 15, 3, 2016. Crossref
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Lee Clare M., Mudaliar Manikhandan A. V., Haggart D. R., Wolf C. Roland, Miele Gino, Vass J. Keith, Higham Desmond J., Crowther Daniel, Homayouni Ramin, Simultaneous Non-Negative Matrix Factorization for Multiple Large Scale Gene Expression Datasets in Toxicology, PLoS ONE, 7, 12, 2012. Crossref
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Cheng Yuanhua, Regnier Michael, Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility, Archives of Biochemistry and Biophysics, 601, 2016. Crossref
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Liu Rong, Jin J.-P., Calponin isoforms CNN 1, CNN 2 and CNN 3: Regulators for actin cytoskeleton functions in smooth muscle and non-muscle cells, Gene, 585, 1, 2016. Crossref
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Yu Zhi-Bin, Wei Hongguang, Jin J.-P., Chronic coexistence of two troponin T isoforms in adult transgenic mouse cardiomyocytes decreased contractile kinetics and caused dilatative remodeling, American Journal of Physiology-Cell Physiology, 303, 1, 2012. Crossref
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Liu Rong, Feng Han-Zhong, Jin J.-P., Physiological contractility of cardiomyocytes in the wall of mouse and rat azygos vein, American Journal of Physiology-Cell Physiology, 306, 7, 2014. Crossref
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Wei Hongguang, Jin J.-P., NH2-terminal truncations of cardiac troponin I and cardiac troponin T produce distinct effects on contractility and calcium homeostasis in adult cardiomyocytes, American Journal of Physiology-Cell Physiology, 308, 5, 2015. Crossref
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Huang Qi-Quan, Hossain M. Moazzem, Sun Wen, Xing Lianping, Pope Richard M., Jin J.-P., Deletion of calponin 2 in macrophages attenuates the severity of inflammatory arthritis in mice, American Journal of Physiology-Cell Physiology, 311, 4, 2016. Crossref
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Feng Han-Zhong, Jin J.-P., Coexistence of cardiac troponin T variants reduces heart efficiency, American Journal of Physiology-Heart and Circulatory Physiology, 299, 1, 2010. Crossref
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England Jennifer, Loughna Siobhan, Rutland Catrin, Multiple Species Comparison of Cardiac Troponin T and Dystrophin: Unravelling the DNA behind Dilated Cardiomyopathy, Journal of Cardiovascular Development and Disease, 4, 3, 2017. Crossref
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Jeong Euy-Myong, Wang Xin, Xu Kun, Hossain M. Moazzem, Jin J.-P., Nonmyofilament-associated troponin T fragments induce apoptosis, American Journal of Physiology-Heart and Circulatory Physiology, 297, 1, 2009. Crossref
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Wei Hongguang, Jin J.-P., A dominantly negative mutation in cardiac troponin I at the interface with troponin T causes early remodeling in ventricular cardiomyocytes, American Journal of Physiology-Cell Physiology, 307, 4, 2014. Crossref
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Akhter Shirin, Zhang Zhiling, Jin J.-P., The heart-specific NH2-terminal extension regulates the molecular conformation and function of cardiac troponin I, American Journal of Physiology-Heart and Circulatory Physiology, 302, 4, 2012. Crossref
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Szeitner Zsuzsanna, Doleschall Anna, Varga Marina, Keltai Katalin, Révész Katalin, Gyurcsányi Róbert E., Mészáros Tamás, Spiegelmers as potential receptors for cTnI diagnostics, Analytical Methods, 9, 35, 2017. Crossref
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Wang Jiajia, Ge Qianqian, Li Jitao, Chen Zhao, Li Jian, Isolation and characterization of three skeletal troponin genes and association with growth-related traits in Exopalaemon carinicauda, Molecular Biology Reports, 46, 1, 2019. Crossref
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Plazyo Olesya, Liu Rong, Moazzem Hossain M., Jin J.-P., Deletion of calponin 2 attenuates the development of calcific aortic valve disease in ApoE−/− mice, Journal of Molecular and Cellular Cardiology, 121, 2018. Crossref
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Barnes Dawn E., Watabe Eichi, Ono Kanako, Kwak Euiyoung, Kuroyanagi Hidehito, Ono Shoichiro, Hardin Jeffrey D., Tropomyosin isoforms differentially affect muscle contractility in the head and body regions of the nematodeCaenorhabditis elegans, Molecular Biology of the Cell, 29, 9, 2018. Crossref
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Feng Han-Zhong, Chen Guozhen, Nan Changlong, Huang Xupei, Jin Jian-Ping, Abnormal splicing in the N-terminal variable region of cardiac troponin T impairs systolic function of the heart with preserved Frank-Starling compensation, Physiological Reports, 2, 9, 2014. Crossref
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Kim Soon-Chan, Hong Chang-Won, Jang Sang-Geun, Kim Ye-Ah, Yoo Byong-Chul, Shin Young-Kyoung, Jeong Seung-Yong, Ku Ja-Lok, Park Jae-Gahb, Establishment and Characterization of Paired Primary and Peritoneal Seeding Human Colorectal Cancer Cell Lines: Identification of Genes That Mediate Metastatic Potential, Translational Oncology, 11, 5, 2018. Crossref
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Larsson Lars, Wang Xin, Yu Fushun, Höök Peter, Borg Kristian, Chong Stephen M., Jin J.-P., Adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease, American Journal of Physiology-Cell Physiology, 295, 3, 2008. Crossref
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Shu Jingting, Ji Gaige, Zhang Ming, Tu Yunjie, Shan Yanju, Liu Yifan, Ju Xiaojun, Zhang Di, Molecular Cloning, Characterization, and Temporal Expression Profile of Troponin I Type 1 (TNNI1) Gene in Skeletal Muscle During Early Development of Gaoyou Duck (Anas Platyrhynchos Domestica), Animal Biotechnology, 30, 2, 2019. Crossref
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Feng Han-Zhong, Wang Hui, Takahashi Katsuhito, Jin J.-P., Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle, Journal of Molecular and Cellular Cardiology, 129, 2019. Crossref
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Valente Mariana, Resende Tatiana Pinho, Nascimento Diana Santos, Burlen-Defranoux Odile, Soares-da-Silva Francisca, Dupont Benoit, Cumano Ana, Pinto-do-Ó Perpétua, Rawlins Emma, Mouse HSA+ immature cardiomyocytes persist in the adult heart and expand after ischemic injury, PLOS Biology, 17, 6, 2019. Crossref
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Cao Tianxin, Thongam Urvashi, Jin Jian-Ping, Invertebrate troponin: Insights into the evolution and regulation of striated muscle contraction, Archives of Biochemistry and Biophysics, 666, 2019. Crossref
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Hao Yun-He, Yu Shu-Yong, Tu Rui-Sha, Cai Yao-Qing, TNNT1, a prognostic indicator in colon adenocarcinoma, regulates cell behaviors and mediates EMT process, Bioscience, Biotechnology, and Biochemistry, 84, 1, 2020. Crossref
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Li Xiang, Xie Shanshan, Qian Lili, Cai Chunbo, Bi Hanfang, Cui Wentao, Identification of genes related to skeletal muscle growth and development by integrated analysis of transcriptome and proteome in myostatin-edited Meishan pigs, Journal of Proteomics, 213, 2020. Crossref
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De Matteis Alessandra, dell’Aquila Massimiliano, Maiese Aniello, Frati Paola, La Russa Raffaele, Bolino Giorgio, Fineschi Vittorio, The Troponin-I fast skeletal muscle is reliable marker for the determination of vitality in the suicide hanging, Forensic Science International, 301, 2019. Crossref
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Plazyo Olesya, Sheng Juan-Juan, Jin J.-P., Downregulation of calponin 2 contributes to the quiescence of lung macrophages, American Journal of Physiology-Cell Physiology, 317, 4, 2019. Crossref
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Hof Danielle, Klingenberg Roland, von Eckardstein Arnold, Sensible Use of High-Sensitivity Troponin Assays, in Calcium-Binding Proteins and RAGE, 963, 2013. Crossref
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Chong Stephen M., Jin J.-P., To Investigate Protein Evolution by Detecting Suppressed Epitope Structures, Journal of Molecular Evolution, 68, 5, 2009. Crossref
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Heizmann Claus W., Ca2+-Binding Proteins of the EF-Hand Superfamily: Diagnostic and Prognostic Biomarkers and Novel Therapeutic Targets, in Calcium-Binding Proteins of the EF-Hand Superfamily, 1929, 2019. Crossref
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Chen Yu, Wang Jinsong, Wang Donghua, Kang Ting, Du Jinghu, Yan Zeqiang, Chen Manyu, TNNT1, negatively regulated by miR‐873, promotes the progression of colorectal cancer, The Journal of Gene Medicine, 22, 2, 2020. Crossref
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Oki Kentaro, Wei Bin, Feng Han‐Zhong, Jin Jian‐Ping, The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy, The Journal of Physiology, 597, 15, 2019. Crossref
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Qiu Zhaoyan, Chu Yi, Xu Bing, Wang Qian, Jiang Mingzuo, Li Xiaowei, Wang Gang, Yu Pengfei, Liu Guoxiao, Wang Hua, Kang Huijie, Liu Jiayu, Zhang Yu, Jin Jian-Ping, Wu Kaichun, Liang Jie, Increased expression of calponin 2 is a positive prognostic factor in pancreatic ductal adenocarcinoma, Oncotarget, 8, 34, 2017. Crossref
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Cao Tianxin, Jin J.-P., Evolution of Flight Muscle Contractility and Energetic Efficiency, Frontiers in Physiology, 11, 2020. Crossref
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van de Locht Martijn, Borsboom Tamara C., Winter Josine M., Ottenheijm Coen A. C., Troponin Variants in Congenital Myopathies: How They Affect Skeletal Muscle Mechanics, International Journal of Molecular Sciences, 22, 17, 2021. Crossref
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Kawai Masataka, Jin Jian-Ping, Mechanisms of Frank-Starling law of the heart and stretch activation in striated muscles may have a common molecular origin, Journal of Muscle Research and Cell Motility, 42, 2, 2021. Crossref
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Cao Tianxin, Sujkowski Alyson, Cobb Tyler, Wessells Robert J., Jin Jian-Ping, The glutamic acid-rich–long C-terminal extension of troponin T has a critical role in insect muscle functions, Journal of Biological Chemistry, 295, 12, 2020. Crossref
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Amarasinghe Chinthaka, Jin J.-P., N-Terminal Hypervariable Region of Muscle Type Isoforms of Troponin T Differentially Modulates the Affinity of Tropomyosin-Binding Site 1, Biochemistry, 54, 24, 2015. Crossref
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Qian Airong, Hsieh Tzu-Bou, Hossain M. Moazzem, Lin Jim J.-C., Jin J.-P., A rapid degradation of calponin 2 is required for cytokinesis, American Journal of Physiology-Cell Physiology, 321, 2, 2021. Crossref
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Zhang Jiang, Zhang Han, Ayaz-Guner Serife, Chen Yi-Chen, Dong Xintong, Xu Qingge, Ge Ying, Phosphorylation, but Not Alternative Splicing or Proteolytic Degradation, Is Conserved in Human and Mouse Cardiac Troponin T, Biochemistry, 50, 27, 2011. Crossref
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Gunther Laura K., Feng Han-Zhong, Wei Hongguang, Raupp Justin, Jin Jian-Ping, Sakamoto Takeshi, Effect of N-Terminal Extension of Cardiac Troponin I on the Ca2+ Regulation of ATP Binding and ADP Dissociation of Myosin II in Native Cardiac Myofibrils, Biochemistry, 55, 12, 2016. Crossref
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Rasmussen Monica, Jin Jian-Ping, Troponin Variants as Markers of Skeletal Muscle Health and Diseases, Frontiers in Physiology, 12, 2021. Crossref
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Hossain M. Moazzem, Zhao Guangyi, Woo Moon-Sook, Wang James H-C., Jin Jian-Ping, Deletion of Calponin 2 in Mouse Fibroblasts Increases Myosin II-Dependent Cell Traction Force, Biochemistry, 55, 43, 2016. Crossref
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Amarasinghe Chinthaka, Hossain M. Moazzem, Jin J.-P., Functional Basis of Three New Recessive Mutations of Slow Skeletal Muscle Troponin T Found in Non-Amish TNNT1 Nemaline Myopathies, Biochemistry, 55, 32, 2016. Crossref
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Hornos Felipe, Feng Han-Zhong, Rizzuti Bruno, Palomino-Schätzlein Martina, Wieczorek David, Neira José L., Jin J.-P., The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect, Journal of Biological Chemistry, 296, 2021. Crossref
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Gollapudi Sampath K., Mamidi Ranganath, Mallampalli Sri Lakshmi, Chandra Murali, The N-Terminal Extension of Cardiac Troponin T Stabilizes the Blocked State of Cardiac Thin Filament, Biophysical Journal, 103, 5, 2012. Crossref
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Kim Gap-Don, Seo Jin-Kyu, Yum Hyeon-Woong, Jeong Jin-Yeon, Yang Han-Sul, Protein markers for discrimination of meat species in raw beef, pork and poultry and their mixtures, Food Chemistry, 217, 2017. Crossref
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Feng Han-Zhong, Chen Xuequn, Hossain M.Moazzem, Jin Jian-Ping, Toad Heart Utilizes Exclusively Slow Skeletal Muscle Troponin T, Journal of Biological Chemistry, 287, 35, 2012. Crossref
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Wei Bin, Gao Jimin, Huang Xu-Pei, Jin J.-P., Mutual Rescues between Two Dominant Negative Mutations in Cardiac Troponin I and Cardiac Troponin T, Journal of Biological Chemistry, 285, 36, 2010. Crossref
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Manning Edward P., Guinto Pia J., Tardiff Jil C., Correlation of Molecular and Functional Effects of Mutations in Cardiac Troponin T Linked to Familial Hypertrophic Cardiomyopathy, Journal of Biological Chemistry, 287, 18, 2012. Crossref
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Akhter Shirin, Jin J.-P., Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T, FEBS Open Bio, 5, 1, 2015. Crossref
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Rasmussen Monica, Feng Han-Zhong, Jin J.-P., Evolution of the N-Terminal Regulation of Cardiac Troponin I for Heart Function of Tetrapods: Lungfish Presents an Example of the Emergence of Novel Submolecular Structure to Lead the Capacity of Adaptation, Journal of Molecular Evolution, 90, 1, 2022. Crossref
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Wang Xi, Kong Chang, Liu Pan, Geng Wujun, Tang Hongli, Berezin Alexander, Identification of Potential Biomarkers for Ryanodine Receptor 1 (RYR1) Mutation-Associated Myopathies Using Bioinformatics Approach, Disease Markers, 2022, 2022. Crossref
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Chalovich J. M., Zhu L., Johnson D., Hypertrophic Cardiomyopathy Mutations of Troponin Reveal Details of Striated Muscle Regulation, Frontiers in Physiology, 13, 2022. Crossref
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Feng Han-Zhong, Wei Bin, Jin Jian-Ping, Deletion of a Genomic Segment Containing the Cardiac Troponin I Gene Knocks Down Expression of the Slow Troponin T Gene and Impairs Fatigue Tolerance of Diaphragm Muscle, Journal of Biological Chemistry, 284, 46, 2009. Crossref
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Rasmussen Monica, Jin Jian-Ping, Monoclonal Antibodies as Probes to Study Ligand-Induced Conformations of Troponin Subunits, Frontiers in Physiology, 13, 2022. Crossref
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Hsieh Tzu-Bou, Feng Han-Zhong, Jin Jian-Ping, Deletion of Calponin 2 Reduces the Formation of Postoperative Peritoneal Adhesions, Journal of Investigative Surgery, 35, 3, 2022. Crossref
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Horiuchi Keiko, Perez-Cerezales Serafín, Papasaikas Panagiotis, Ramos-Ibeas Priscila, López-Cardona Angela Patricia, Laguna-Barraza Ricardo, Fonseca Balvís Noelia, Pericuesta Eva, Fernández-González Raul, Planells Benjamín, Viera Alberto, Suja Jose Angel, Ross Pablo Juan, Alén Francisco, Orio Laura, Rodriguez de Fonseca Fernando, Pintado Belén, Valcárcel Juan, Gutiérrez-Adán Alfonso, Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice, Cell Reports, 23, 1, 2018. Crossref
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Cao Tianxin, Akhter Shirin, Jin J.-P., Early Divergence of the C-Terminal Variable Region of Troponin T Via a Pair of Mutually Exclusive Alternatively Spliced Exons Followed by a Selective Fixation in Vertebrate Heart, Journal of Molecular Evolution, 2022. Crossref
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Hsieh Tzu‐Bou, Jin Jian‐Ping, Loss of Calponin 2 causes age‐progressive proteinuria in mice, Physiological Reports, 10, 18, 2022. Crossref